PIM-IN-72 is a less active enantiomer of LGH447 (GLXC-10644), acting as a selective weak pan-PIM inhibitor (IC50 (µM): PIM1 0.095; PIM2 0.522; PIM3 0.369) in comparision with LGH447 (IC50 (µM): PIM1 0.001; PIM2 0.002; PIM3 0.002).
MedKoo Cat#: 533656
Name: PIM-IN-72
CAS#: N/A
Chemical Formula: C24H23F3N4O
Exact Mass: 440.1824
Molecular Weight: 440.47
Elemental Analysis: C, 65.44; H, 5.26; F, 12.94; N, 12.72; O, 3.63
The following data is based on the product molecular weight 440.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
