Propargyl-PEG4-acid is a bifunctional triethyleneglycol derivative bearing a carboxy group, and an alkyne moiety. The former can be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. The alkyne group can be coupled with azides in a CuAAc reaction. PEGs are hydrophilic linkers that are useful in the synthesis of water soluble conjugates.
MedKoo Cat#: 558981
Name: Propargyl-PEG4-acid
CAS#: 1415800-32-6
Chemical Formula: C12H20O6
Exact Mass: 260.1260
Molecular Weight: 260.29
Elemental Analysis: C, 55.37; H, 7.75; O, 36.88
The following data is based on the product molecular weight 260.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
