MedKoo Cat#: 533630 | Name: HOIPIN-1
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HOIPIN-1, also known as JTP-0819958, is a novel selective inhibitor of linear ubiquitin chain assembly complex (LUBAC).

Chemical Structure

HOIPIN-1
HOIPIN-1
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 533630

Name: HOIPIN-1

CAS#: N/A

Chemical Formula: C17H13NaO4

Exact Mass: 304.0712

Molecular Weight: 304.28

Elemental Analysis: C, 67.11; H, 4.31; Na, 7.56; O, 21.03

Price and Availability

Size Price Availability Quantity
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 7,450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
HOIPIN-1; HOIPIN 1; HOIPIN1; JTP-0819958; JTP 0819958; JTP0819958;
IUPAC/Chemical Name
Sodium 2-[(E)-3-(2-methoxyphenyl)-3-oxoprop-1-enyl]benzoate
InChi Key
JCKWBPCGGVUJEV-ASTDGNLGSA-M
InChi Code
InChI=1S/C17H14O4.Na/c1-21-16-9-5-4-8-14(16)15(18)11-10-12-6-2-3-7-13(12)17(19)20;/h2-11H,1H3,(H,19,20);/q;+1/p-1/b11-10+;
SMILES Code
O=C([O-])C1=CC=CC=C1/C=C/C(C2=CC=CC=C2OC)=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706. doi: 10.1016/j.bbrc.2018.12.164. Epub 2019 Jan 2. PMID: 30611571. 2: Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses. Commun Biol. 2020 Apr 3;3(1):163. doi: 10.1038/s42003-020-0882-8. PMID: 32246052; PMCID: PMC7125101. 3: Wu B, Li J, Wang H, Liu J, Li J, Sun F, Feng DC. RIPK1 is aberrantly expressed in multiple B-cell cancers and implicated in the underlying pathogenesis. Discov Oncol. 2023 Jul 18;14(1):131. doi: 10.1007/s12672-023-00725-z. PMID: 37462822; PMCID: PMC10353973.