Synonym
HOIPIN-1; HOIPIN 1; HOIPIN1; JTP-0819958; JTP 0819958; JTP0819958;
IUPAC/Chemical Name
Sodium 2-[(E)-3-(2-methoxyphenyl)-3-oxoprop-1-enyl]benzoate
InChi Key
JCKWBPCGGVUJEV-ASTDGNLGSA-M
InChi Code
InChI=1S/C17H14O4.Na/c1-21-16-9-5-4-8-14(16)15(18)11-10-12-6-2-3-7-13(12)17(19)20;/h2-11H,1H3,(H,19,20);/q;+1/p-1/b11-10+;
SMILES Code
O=C([O-])C1=CC=CC=C1/C=C/C(C2=CC=CC=C2OC)=O.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
304.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga
F. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC),
HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb
12;509(3):700-706. doi: 10.1016/j.bbrc.2018.12.164. Epub 2019 Jan 2. PMID:
30611571.
2: Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S,
Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S,
Tanaka K, Saeki Y, Fukai S, Tokunaga F. Molecular bases for HOIPINs-mediated
inhibition of LUBAC and innate immune responses. Commun Biol. 2020 Apr
3;3(1):163. doi: 10.1038/s42003-020-0882-8. PMID: 32246052; PMCID: PMC7125101.
3: Wu B, Li J, Wang H, Liu J, Li J, Sun F, Feng DC. RIPK1 is aberrantly
expressed in multiple B-cell cancers and implicated in the underlying
pathogenesis. Discov Oncol. 2023 Jul 18;14(1):131. doi:
10.1007/s12672-023-00725-z. PMID: 37462822; PMCID: PMC10353973.