MedKoo Cat#: 574296 | Name: Chloroguanabenz acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chloroguanabenz acetate is an antiprion agent. It is derived from the α2-adrenergic receptor agonist guanabenz. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington’s disease.

Chemical Structure

Chloroguanabenz acetate
Chloroguanabenz acetate
CAS#None

Theoretical Analysis

MedKoo Cat#: 574296

Name: Chloroguanabenz acetate

CAS#: None

Chemical Formula: C10H11Cl3N4O2

Exact Mass: 0.0000

Molecular Weight: 325.57

Elemental Analysis: C, 36.89; H, 3.41; Cl, 32.67; N, 17.21; O, 9.83

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 Back order
5mg USD 650.00 Back order
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Related CAS #
No Data
Synonym
Guanabenz acetate; Wytensin; WY-8678 acetate; WY8678 acetate; WY 8678 acetate
IUPAC/Chemical Name
(E)-2-(2,3,6-trichlorobenzylidene)hydrazine-1-carboximidamide, monoacetate
InChi Key
GKLCICRSHLCLBI-UFJIHACCSA-N
InChi Code
InChI=1S/C8H7Cl3N4.C2H4O2/c9-5-1-2-6(10)7(11)4(5)3-14-15-8(12)13;1-2(3)4/h1-3H,(H4,12,13,15);1H3,(H,3,4)/b14-3+;
SMILES Code
ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1Cl.OC(C)=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tribouillard-Tanvier, D., Béringue, V., Desban, N., et al. Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One 3(4), e1981 (2008). 2. Bertolotti, A., and Blondel, M. Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases. (2011).