DDD01035881 is a novel transmission blocker of antimalarials, targeting male gametes. DDD01035881 exhibits potent transmission-blocking activity against Plasmodium falciparum by targeting the vacuole membrane protein Pfs16. In vitro assays demonstrated that DDD01035881 effectively inhibits gametocyte activation, with an IC₅₀ of 0.22 μM. Furthermore, in vivo studies using a mouse model of malaria transmission showed that administration of DDD01035881 significantly reduced oocyst formation in mosquitoes, indicating its potential to block parasite development within the vector.
MedKoo Cat#: 533599
Name: DDD01035881
CAS#: 1396858-56-2
Chemical Formula: C14H14BrNO4S2
Exact Mass: 402.9548
Molecular Weight: 404.29
Elemental Analysis: C, 41.59; H, 3.49; Br, 19.76; N, 3.46; O, 15.83; S, 15.86
The following data is based on the product molecular weight 404.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
