Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats due to induction of hypertrophy and reduction in the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids.
MedKoo Cat#: 574275
Name: Cholestanone
CAS#: 601-57-0
Chemical Formula: C27H44O
Exact Mass: 384.3392
Molecular Weight: 384.65
Elemental Analysis: C, 84.31; H, 11.53; O, 4.16
The following data is based on the product molecular weight 384.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
