Indoramin | CAS#26844-12-2 | antihypertensive

MedKoo Cat#: 585425 | Name: Indoramin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indoramin is an alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.

Chemical Structure

Indoramin

CAS#26844-12-2

Theoretical Analysis

MedKoo Cat#: 585425

Name: Indoramin

CAS#: 26844-12-2

Chemical Formula: C22H25N3O

Exact Mass: 347.1998

Molecular Weight: 347.46

Elemental Analysis: C, 76.05; H, 7.25; N, 12.09; O, 4.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Indoramin; WY 21901; WY21901; WY-21901

IUPAC/Chemical Name

N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide

InChi Key

JXZZEXZZKAWDSP-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)

SMILES Code

O=C(NC1CCN(CCC2=CNC3=C2C=CC=C3)CC1)C4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 347.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nelson RL, Thomas K, Morgan J, Jones A. Non surgical therapy for anal fissure. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD003431. doi: 10.1002/14651858.CD003431.pub3. Review. PubMed PMID: 22336789. 2: Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Jul;35(1):9-36. Review. PubMed PMID: 9673832. 3: Holmes B, Sorkin EM. Indoramin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and related vascular, cardiovascular and airway diseases. Drugs. 1986 Jun;31(6):467-99. Review. Erratum in: Drugs 1986 Oct;32(4):preceding 291. PubMed PMID: 3525084. 4: Pierce DM. A review of the clinical pharmacokinetics and metabolism of the alpha 1-adrenoceptor antagonist indoramin. Xenobiotica. 1990 Dec;20(12):1357-67. Review. PubMed PMID: 1981634. 5: Indoramin. Lancet. 1981 Jun 6;1(8232):1243-4. PubMed PMID: 6112572. 6: Seth L, Galiè N, Casebolt P, Gimenez H, Malloy M, Franciosa JA. Indoramin in heart failure: possible adverse effects on hemodynamics and exercise capacity. Clin Pharmacol Ther. 1986 Nov;40(5):567-74. PubMed PMID: 3769387. 7: Bache RJ, Homans DC, Schwartz JS, Dai XZ. Differences in the effects of alpha-1 adrenergic blockade with prazosin and indoramin on coronary blood flow during exercise. J Pharmacol Exp Ther. 1988 Apr;245(1):232-7. PubMed PMID: 2896237. 8: Digne-Malcolm H, Frise MC, Dorrington KL. How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure. Front Physiol. 2016 Jul 29;7:320. doi: 10.3389/fphys.2016.00320. eCollection 2016. Review. PubMed PMID: 27524972; PubMed Central PMCID: PMC4965470. 9: Bennett JM, Weich DJ, Schoeman HS. Double-blind study comparing indoramin and propranolol in the treatment of black patients with hypertension. S Afr Med J. 1988 Dec 17;74(12):619-21. PubMed PMID: 3061032. 10: Muller CA, Worthington MG, Thandroyen FT. Antiarrhythmic and metabolic effects of indoramin during acute regional ischemia and reperfusion in isolated rat heart. J Cardiovasc Pharmacol. 1990 Mar;15(3):408-13. PubMed PMID: 1691364. 11: Alps BJ, Hill M, Johnson ES, Wilson AB. Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901). Br J Pharmacol. 1972 Jan;44(1):52-62. PubMed PMID: 4401308; PubMed Central PMCID: PMC1665700. 12: Pierce V, Shepperson NB, Todd MH, Waterfall JF. Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin. Br J Pharmacol. 1986 Feb;87(2):433-41. PubMed PMID: 3955309; PubMed Central PMCID: PMC1916533. 13: Schabort I, Odendaal HJ, Pierce DM. The pharmacokinetics of oral indoramin during pregnancy. Br J Clin Pharmacol. 1990 Apr;29(4):397-401. PubMed PMID: 2328193; PubMed Central PMCID: PMC1380108. 14: Abrams SM, Pierce DM, Johnston A, Hedges A, Franklin RA, Turner P. Pharmacokinetic interaction between indoramin and ethanol. Hum Toxicol. 1989 May;8(3):237-41. PubMed PMID: 2744781. 15: Archibald JL, Turner P. Indoramin in the treatment of hypertension. A mini-review and update. S Afr Med J. 1983 Feb 26;63(9):307-9. Review. PubMed PMID: 6338605. 16: Deitch MW, Allen IE, Pascucci VL. Antihypertensive therapy with indoramin in the elderly. J Cardiovasc Pharmacol. 1986;8 Suppl 2:S88-92. PubMed PMID: 2423807. 17: Ishizuka O, Pandita RK, Mattiasson A, Steers WD, Andersson KE. Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):787-93. PubMed PMID: 9205965. 18: Ghose K, Coppen A, Carrol D. Intravenous tyramine response in migraine before and during treatment with indoramin. Br Med J. 1977 May 7;1(6070):1191-3. PubMed PMID: 324566; PubMed Central PMCID: PMC1606859. 19: Pitt J, Dawson PM, Hallan RI, Boulos PB. A double-blind randomized placebo-controlled trial of oral indoramin to treat chronic anal fissure. Colorectal Dis. 2001 May;3(3):165-8. PubMed PMID: 12790983. 20: Antani J, Buckle JW, Turner J, Cohen M. A double-blind comparison of indoramin and propranolol in the treatment of moderate to severe essential hypertension. Curr Med Res Opin. 1983;8(9):603-11. PubMed PMID: 6365463.