MedKoo Cat#: 533432 | Name: SU0383

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SU0383 is a potent and selective OGG1 inhibitor. DNA glycosylases involved in the first step of the DNA base excision repair pathway are promising targets in cancer therapy. There is evidence that reduction of their activities may enhance cell killing in malignant tumors.

Chemical Structure

SU0383
SU0383
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 533432

Name: SU0383

CAS#: unknown

Chemical Formula: C33H34N6O5S

Exact Mass: 626.2311

Molecular Weight: 626.73

Elemental Analysis: C, 63.24; H, 5.47; N, 13.41; O, 12.76; S, 5.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SU0383; SU-0383; SU 0383;
IUPAC/Chemical Name
N-(2-((2-amino-5-methylpyrimidin-4-yl)oxy)ethyl)-4'-(N-(1-(cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide
InChi Key
KIUIIVGLTWYGNU-UHFFFAOYSA-N
InChi Code
InChI=1S/C33H34N6O5S/c1-21-20-36-33(34)37-31(21)44-17-15-35-30(40)26-5-2-4-25(18-26)22-10-13-28(14-11-22)45(42,43)38-27-12-9-23-6-3-16-39(29(23)19-27)32(41)24-7-8-24/h2,4-5,9-14,18-20,24,38H,3,6-8,15-17H2,1H3,(H,35,40)(H2,34,36,37)
SMILES Code
NC1=NC(OCCNC(C2=CC=CC(C3=CC=C(S(NC4=CC=C5C(N(C(C6CC6)=O)CCC5)=C4)(=O)=O)C=C3)=C2)=O)=C(C)C=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 626.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kant M, Tahara YK, Jaruga P, Coskun E, Lloyd RS, Kool ET, Dizdaroglu M. Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions. ACS Chem Biol. 2020 Dec 17. doi: 10.1021/acschembio.0c00877. Epub ahead of print. PMID: 33331782. 2: Tahara YK, Kietrys AM, Hebenbrock M, Lee Y, Wilson DL, Kool ET. Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1. ACS Chem Biol. 2019 Dec 20;14(12):2606-2615. doi: 10.1021/acschembio.9b00490. Epub 2019 Oct 29. PMID: 31622553; PMCID: PMC7061906.