Synonym
WR 30090; WR30090; WR-30090
IUPAC/Chemical Name
2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)quinolin-4-yl]ethanol
InChi Key
PGLJCSZNFGDTFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H28Cl4N2O/c1-3-5-9-31(10-6-4-2)15-24(32)18-14-23(16-7-8-20(27)21(28)11-16)30-25-19(18)12-17(26)13-22(25)29/h7-8,11-14,24,32H,3-6,9-10,15H2,1-2H3
SMILES Code
ClC1=CC=C(C2=NC3=C(Cl)C=C(Cl)C=C3C(C(O)CN(CCCC)CCCC)=C2)C=C1Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
514.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Clyde DF, McCarthy VC, Rebert CC, Miller RM. Prophylactic activity of a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090) in human malaria. Antimicrob Agents Chemother. 1973 Feb;3(2):220-3. PubMed PMID: 4597716; PubMed Central PMCID: PMC444390.
2: Canfield CJ, Hall AP, MacDonald BS, Neuman DA, Shaw JA. Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090). Antimicrob Agents Chemother. 1973 Feb;3(2):224-7. PubMed PMID: 4597717; PubMed Central PMCID: PMC444391.
3: Martin DC, Arnold JD, Clyde DF, al-Ibrahim M, Carson PE, Rieckmann KH, Willerson D Jr. A quinoline methanol (WR 30090) for treatment of acute malaria. Antimicrob Agents Chemother. 1973 Feb;3(2):214-9. PubMed PMID: 4597715; PubMed Central PMCID: PMC444389.
4: Mu JY, Israili ZH, Dayton PG. Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090. Drug Metab Dispos. 1975 May-Jun;3(3):198-210. PubMed PMID: 238819.
5: Karle JM, Olmeda R, Gerena L, Milhous WK. Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents. Exp Parasitol. 1993 Jun;76(4):345-51. PubMed PMID: 8513873.
6: Stella V, Haslam J, Yata N, Okada H, Lindenbaum S, Higuchi T. Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule. J Pharm Sci. 1978 Oct;67(10):1375-7. PubMed PMID: 702283.
