IUPAC/Chemical Name
(1R,2S,5R,5aS,5bS,8R,8aS,9R,11aR,13aR)-2,3,4,5,5a,5b,8,8a,9,10,13,13a-dodecahydro-2-hydroxy-5,7,8-trimethyl-9-(2-methylpropyl)-1,5-epoxy-1H-cyclohepta[3,4]benz[1,2-d]isoindole-11,12-dione
InChi Key
AQZDMONQDXTWHN-XLFKICHRSA-N
InChi Code
InChI=1S/C24H35NO4/c1-11(2)8-16-19-13(4)12(3)9-15-20-14(10-18(27)24(15,19)22(28)25-16)21-17(26)6-7-23(20,5)29-21/h9,11,13-17,19-21,26H,6-8,10H2,1-5H3,(H,25,28)/t13-,14+,15-,16+,17-,19+,20+,21+,23+,24-/m1/s1
SMILES Code
CC1=C[C@@]([C@]2([H])[C@@](C3)([H])[C@@]4([H])[C@H](O)CC[C@@]2(O4)C)([H])[C@@]([C@@]5([H])[C@@H]1C)(C(N[C@H]5CC(C)C)=O)C3=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
404.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Canham SM, Overman LE, Tanis PS. Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ. Tetrahedron. 2011 Dec 23;67(51):9837-9843. doi: 10.1016/j.tet.2011.09.079. Epub 2011 Sep 19. PMID: 22518066; PMCID: PMC3327308.
6: Zhang Y, Wang T, Pei Y, Hua H, Feng B. Aspergillin PZ, a novel isoindole- alkaloid from Aspergillus awamori. J Antibiot (Tokyo). 2002 Aug;55(8):693-5. doi: 10.7164/antibiotics.55.693. PMID: 12374381.
