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MedKoo Cat#: 471046 | Name: EMPA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EMPA is a potent, reversible and selective OX2R antagonist; brain penetrant.

Chemical Structure

EMPA
EMPA
CAS#680590-49-2

Theoretical Analysis

MedKoo Cat#: 471046

Name: EMPA

CAS#: 680590-49-2

Chemical Formula: C23H26N4O4S

Exact Mass: 454.1675

Molecular Weight: 454.55

Elemental Analysis: C, 60.78; H, 5.77; N, 12.33; O, 14.08; S, 7.05

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,450.00 2 Weeks
2g USD 5,650.00 2 Weeks
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Related CAS #
No Data
Synonym
EMPA
IUPAC/Chemical Name
N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide
InChi Key
KJPHTXTWFHVJIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3
SMILES Code
O=C(N(CC)CC1=CC=CN=C1)CN(C2=CC=C(OC)N=C2)S(=O)(C3=CC=CC=C3C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Malherbe, P., Borroni, E., Gobbi, L., et al. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor. Br. J. Pharmacol. 156(8), 1326-1341 (2009) 2. Malherbe P. et al. Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA). Mol Pharmacol. 2010 Jul;78(1):81-93. doi: 10.1124/mol.110.064584. Epub 2010 Apr 19. 3. Mochizuki T. et al. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4471-6. doi: 10.1073/pnas.1012456108. Epub 2011 Feb 28.