rTRD01 is a novel TDP-43 ligand, binding to TDP-43's RRM1 and RRM2 domains, partially disrupting TDP-43's interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene, improving larval turning, an assay measuring neuromuscular coordination and strength.
MedKoo Cat#: 533353
Name: rTRD01
CAS#: 1332175-56-0
Chemical Formula: C18H21FN4O2
Exact Mass: 344.1649
Molecular Weight: 344.39
Elemental Analysis: C, 62.78; H, 6.15; F, 5.52; N, 16.27; O, 9.29
The following data is based on the product molecular weight 344.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
