Tanshinone I | CAS# 568-73-0 | Diterpene

MedKoo Cat#: 574202 | Name: Tanshinone I

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tanshinone I is a diterpene with anticancer, antidiabetic, and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity and inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells. It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia. It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function.

Chemical Structure

Tanshinone I

CAS#568-73-0

Theoretical Analysis

MedKoo Cat#: 574202

Name: Tanshinone I

CAS#: 568-73-0

Chemical Formula: C18H12O3

Exact Mass: 276.0786

Molecular Weight: 276.29

Elemental Analysis: C, 78.25; H, 4.38; O, 17.37

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 300.00
10mg	USD 450.00
25mg	USD 750.00
50mg	USD 1,250.00

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Related CAS #

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Synonym

Tanshinone I, Tanshinone A

IUPAC/Chemical Name

1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione

InChi Key

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

SMILES Code

O=C(C1=C2C(C(C)=CC=C2)=CC=C1C3=C4C(C)=CO3)C4=O

Appearance

A crystalline solid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lu Z, Liao H, Zhang M, Huang M, Du M, Wang Y, Zhao Z, Shi S, Zhu Z. Tanshinone I inhibits the functions of T lymphocytes and exerts therapeutic effects on delayed-type hypersensitivity reaction via blocking STATs signaling pathways. Eur J Pharmacol. 2024 Nov 11:177128. doi: 10.1016/j.ejphar.2024.177128. Epub ahead of print. PMID: 39536856. 2: Li Y, Guo Z, Li P, Guo J, Wang H, Pan W, Wu F, Li J, Zhou J, Ma Z. Tanshinone T1/T2A inhibits non-small cell lung cancer through Lin28B-let-7-BORA/MYC regulatory network. Gene. 2024 Oct 29;935:149058. doi: 10.1016/j.gene.2024.149058. Epub ahead of print. PMID: 39481768. 3: Zhang J, Meng X, Qin Q, Liang Y, Yang G, Li S, Li X, Zhou JC, Sun L. Evaluation of the Role of Tanshinone I in an In Vitro System of Charcot-Marie- Tooth Disease Type 2N. Int J Mol Sci. 2024 Oct 17;25(20):11184. doi: 10.3390/ijms252011184. PMID: 39456965; PMCID: PMC11509018. 4: RETRACTION: Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway. Cell Prolif. 2024 Oct 23:e13768. doi: 10.1111/cpr.13768. Epub ahead of print. PMID: 39443824. 5: Xue-Zhang, Li CY, Zhu GH, Song LL, Zhao YW, Ma YH, Ping-Tian, Chen WS, Ge GB. Discovery of Tetrahydro Tanshinone I as a Naturally Occurring Covalent Pan-Inhibitor Against Gut Microbial Bile Salt Hydrolases. J Agric Food Chem. 2024 Oct 23;72(42):23233-23245. doi: 10.1021/acs.jafc.4c03617. Epub 2024 Oct 8. PMID: 39378230. 6: Hu C, He X, Zhang H, Hu X, Liao L, Cai M, Lin Z, Xiang J, Jia X, Lu G, Xiao W, Feng Y, Gong W. Tanshinone I limits inflammasome activation of macrophage via docking into Syk to alleviate DSS-induced colitis in mice. Mol Immunol. 2024 Sep;173:88-98. doi: 10.1016/j.molimm.2024.07.007. Epub 2024 Jul 31. PMID: 39088935. 7: Ji Z, Sun B, Yang T, Li X, Zhang Z, Bao M, Zhao L, Lou H, Li Y, Sun G, Huang J. Holistic quality assessment and monitoring of YiXinShu capsule based on three-dimensional fingerprints combined with quantitative analysis, antioxidant activity and chemometrics. J Ethnopharmacol. 2024 Dec 5;335:118630. doi: 10.1016/j.jep.2024.118630. Epub 2024 Jul 23. PMID: 39053720. 8: Xing Z, Bi G, Li T, Zhang Q, Knight PR. Effect of Harvest Time on Growth and Bioactive Compounds in Salvia miltiorrhiza. Plants (Basel). 2024 Jun 28;13(13):1788. doi: 10.3390/plants13131788. PMID: 38999628; PMCID: PMC11243644. 9: Tang X, Gong J, Ren L, Wang Z, Yang B, Wang W, Wang N. Tanshinone I improves TNBC chemosensitivity by suppressing late-phase autophagy through AKT/p38 MAPK signaling pathway. Biomed Pharmacother. 2024 Aug;177:117037. doi: 10.1016/j.biopha.2024.117037. Epub 2024 Jul 2. PMID: 38959602. 10: Wang J, Guo Y, Zhou H, Hua Y, Wan H, Yang J. Investigating the Mechanistic of Danhong Injection in Brain Damage Caused by Cardiac I/R Injury via Bioinformatics, Computer Simulation, and Experimental Validation. ACS Omega. 2024 Apr 11;9(16):18341-18357. doi: 10.1021/acsomega.4c00200. PMID: 38680343; PMCID: PMC11044240. 11: Wang G, Li Y, Guo Z, He Q, Liu Z, Deng B. Tanshinone I Stimulates Pyroptosis of Cisplatin-Resistant Gastric Cancer Cells by Activating the NF- κB/Caspase-3(8)/GSDME Signaling Pathway. DNA Cell Biol. 2024 Apr;43(4):185-196. doi: 10.1089/dna.2023.0293. Epub 2024 Mar 11. PMID: 38466945. 12: Xu H, Guo NN, Zhu CY, Ye LY, Yan XY, Liu YQ, Zhang ZY, Zhang G, Hussain L. Diterpenoid Tanshinones Can Inhibit Lung Cancer Progression by Improving the Tumor Microenvironment and Downregulation of NF-κB Expression. ACS Omega. 2024 Feb 2;9(6):7230-7238. doi: 10.1021/acsomega.3c09667. Erratum in: ACS Omega. 2024 Apr 23;9(18):20636. doi: 10.1021/acsomega.4c03026. PMID: 38371808; PMCID: PMC10870295. 13: Zhang L, Tao S, Zhang Y, Yang Y, Peng F, Liao H, Mao C, Wan X, Wu Y, Xu Z, Zhang C. Study on the effect of compound cultivation on the growth feature and active ingredients content of Salvia miltiorrhiza. Front Plant Sci. 2024 Jan 18;14:1238896. doi: 10.3389/fpls.2023.1238896. PMID: 38343765; PMCID: PMC10854009. 14: Li D, Liu Y, Chen G, Yan Y, Bai Z. The SmERF1b-like regulates tanshinone biosynthesis in Salvia miltiorrhiza hairy root. AoB Plants. 2023 Dec 8;16(1):plad086. doi: 10.1093/aobpla/plad086. PMID: 38249522; PMCID: PMC10799320. 15: Ayvazyan A, Deutsch L, Zidorn C, Kircher B, Çiçek SS. Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza). Front Plant Sci. 2023 Dec 4;14:1269710. doi: 10.3389/fpls.2023.1269710. PMID: 38116152; PMCID: PMC10729661. 16: Ma C, Wang Z, Mo L, Wang X, Zhou G, Yi C, Niu W, Liu Y. Tanshinone I attenuates estrogen-deficiency bone loss via inhibiting RANKL-induced MAPK and NF-κB signaling pathways. Int Immunopharmacol. 2024 Jan 25;127:111322. doi: 10.1016/j.intimp.2023.111322. Epub 2023 Dec 7. PMID: 38064814. 17: Debroy B, De A, Bhattacharya S, Pal K. In silico screening of herbal phytochemicals to develop a Rasayana for immunity against Nipah virus. J Ayurveda Integr Med. 2023 Nov-Dec;14(6):100825. doi: 10.1016/j.jaim.2023.100825. Epub 2023 Dec 3. PMID: 38048723; PMCID: PMC10746367. 18: Xia M, Wu Y, Zhu H, Duan W. Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway. Hum Exp Toxicol. 2023 Jan- Dec;42:9603271231216963. doi: 10.1177/09603271231216963. PMID: 37989263. 19: Chen J, Yin Z, Yu N, Ou S, Wang X, Li H, Zhu H. Tanshinone Alleviates UVA- induced Melanogenesis in Melanocytes via the Nrf2-regulated Antioxidant Defense Signaling Pathway. Curr Mol Med. 2024;24(12):1529-1539. doi: 10.2174/0115665240263196230920161019. PMID: 37921187. 20: Tiwari A, Tiwari V, Sharma A, Singh D, Singh Rawat M, Virmani T, Virmani R, Kumar G, Kumar M, Alhalmi A, Noman OM, Mothana RA, Alali M. Corrigendum to "Tanshinone-I for the treatment of uterine fibroids: Molecular docking, simulation, and density functional theory investigations" [Saudi Pharm. J. 31(6) (2023) 1061-1067]. Saudi Pharm J. 2023 Oct;31(10):101782. doi: 10.1016/j.jsps.2023.101782. Epub 2023 Sep 15. Erratum for: Saudi Pharm J. 2023 Jun;31(6):1061-1076. doi: 10.1016/j.jsps.2023.05.002. PMID: 37881648; PMCID: PMC10593939.