MedKoo Cat#: 574193 | Name: Antibiotic TS 885
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antibiotic TS 885 is a microbial metabolite that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro. 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.

Chemical Structure

Antibiotic TS 885
Antibiotic TS 885
CAS#51867-94-8

Theoretical Analysis

MedKoo Cat#: 574193

Name: Antibiotic TS 885

CAS#: 51867-94-8

Chemical Formula: C17H25NO4

Exact Mass: 307.1784

Molecular Weight: 307.39

Elemental Analysis: C, 66.43; H, 8.20; N, 4.56; O, 20.82

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Synonym
9-Methylstreptimidone; Antibiotic TS 885; Antibiotic TS-885; Antibiotic TS885; NSC 248958; NSC248958; NSC-248958
IUPAC/Chemical Name
4-[(2R,5S,6E,8Z)-2-hydroxy-5,7-dimethyl-4-oxo-6,8-decadien-1-yl]-2,6-piperidinedione
InChi Key
ATUBIBZJAGAIBW-WGEALTPQSA-N
InChi Code
InChI=1S/C17H25NO4/c1-4-5-11(2)6-12(3)15(20)10-14(19)7-13-8-16(21)18-17(22)9-13/h4-6,12-14,19H,7-10H2,1-3H3,(H,18,21,22)/b5-4-,11-6+/t12-,14+/m0/s1
SMILES Code
C/C=C\C(C)=C\[C@@H](C(C[C@H](O)CC1CC(NC(C1)=O)=O)=O)C
Appearance
A residue
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 307.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Saito, N., Kitame, F., Kikuchi, M., et al. Studies on a new antiviral antibiotic, 9-methylstreptimidone. I. Physicochemical and biological properties. J. Antibiot. (Tokyo) 27(3), 206-214 (1974). 2. Saito, N., Suzuki, F., Sasaki, K., et al. Antiviral and interferon-inducing activity of a new glutarimide antibiotic, 9-methylstreptimidone. Antimicrob. Agents Chemother. 10(1), 14-19 (1976). 3. Umenai, T., Suzuki, F., and Ishida, N. Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice. Antimicrob. Agents Chemother. 13(6), 939-943 (1978).