MedKoo Cat#: 574183 | Name: Nybomycin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nybomycin is a fungal metabolite with antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae. Nybomycin is also active against M. tuberculosis and M. bovis.

Chemical Structure

Nybomycin
Nybomycin
CAS#30408-30-1

Theoretical Analysis

MedKoo Cat#: 574183

Name: Nybomycin

CAS#: 30408-30-1

Chemical Formula: C16H14N2O4

Exact Mass: 298.0954

Molecular Weight: 298.30

Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45

Price and Availability

Size Price Availability Quantity
2mg USD 1,400.00 2 Weeks
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Related CAS #
No Data
Synonym
NSC 613948, Nybomycin
IUPAC/Chemical Name
8-(hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione
InChi Key
HKMUGCUFXWTNSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2O4/c1-8-3-13(21)18-7-22-16-14-11(5-10(8)15(16)18)9(6-19)4-12(20)17(14)2/h3-5,19H,6-7H2,1-2H3
SMILES Code
CN(C(C=C1CO)=O)C2=C1C=C(C(C)=C3)C4=C2OCN4C3=O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties.
In vitro activity:
Compound 1 (nybomycin) showed anti-microbial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG with the MIC of 1.0μg/mL under both actively growing aerobic conditions and dormancy inducing hypoxic conditions. Compound 1 is also effective to Mycobacterium tuberculosis including the clinically isolated strains. Reference: Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. https://pubmed.ncbi.nlm.nih.gov/25934225/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 298.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Shiriaev DI, Sofronova AA, Berdnikovich EA, Lukianov DA, Komarova ES, Marina VI, Zakalyukina YV, Biryukov MV, Maviza TP, Ivanenkov YA, Sergiev PV, Osterman IA, Dontsova OA. Nybomycin inhibits both types of E. coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant. Antimicrob Agents Chemother. 2023 May 1;95(5):e00777-20. doi: 10.1128/AAC.00777-20. Epub 2021 Feb 16. PMID: 33593838; PMCID: PMC8092900. 2. Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17. PMID: 25934225.
In vitro protocol:
1. Shiriaev DI, Sofronova AA, Berdnikovich EA, Lukianov DA, Komarova ES, Marina VI, Zakalyukina YV, Biryukov MV, Maviza TP, Ivanenkov YA, Sergiev PV, Osterman IA, Dontsova OA. Nybomycin inhibits both types of E. coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant. Antimicrob Agents Chemother. 2023 May 1;95(5):e00777-20. doi: 10.1128/AAC.00777-20. Epub 2021 Feb 16. PMID: 33593838; PMCID: PMC8092900. 2. Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17. PMID: 25934225.
In vivo protocol:
TBD
1. Strelitz, F., Flon, H., and Asheshov, I.N. Nybomycin, a new antibiotic with antiphage and antibacterial properties. Proc. Natl. Acad. Sci. U.S.A. 41(9), 620-624 (1955). 2. Arai, M., Kamiya, K., Pruksakorn, P., et al. Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp. Bioorg. Med. Chem. 23(13), 3534-3541 (2015).