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MedKoo Cat#: 574166 | Name: Peimisine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peimisine HCl is a steroidal alkaloid that inhibits lung acetylcholinesterase (AChE).

Chemical Structure

Peimisine HCl
Peimisine HCl
CAS#900498-44-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 574166

Name: Peimisine HCl

CAS#: 900498-44-4 (HCl)

Chemical Formula: C27H42ClNO3

Exact Mass: 463.2853

Molecular Weight: 464.09

Elemental Analysis: C, 69.88; H, 9.12; Cl, 7.64; N, 3.02; O, 10.34

Price and Availability

Size Price Availability Quantity
10mg USD 525.00 2 weeks
25mg USD 850.00 2 weeks
50mg USD 1,350.00 2 weeks
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Related CAS #
19773-24-1 (free base); 900498-44-4 (HCl)
Synonym
Peimisine HCl, Peimisine Hydrochloride
IUPAC/Chemical Name
(2'R,3S,3'R,3'aS,4aS,6'S,6aR,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',4a,5',6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-5(6H)-one, monohydrochloride
InChi Key
BVYFGCQMQQGAEY-MCZYSGEJSA-N
InChi Code
InChI=1S/C27H41NO3.ClH/c1-14-9-24-25(28-13-14)16(3)27(31-24)8-6-18-19(15(27)2)11-21-20(18)12-23(30)22-10-17(29)5-7-26(21,22)4;/h14,16-18,20-22,24-25,28-29H,5-13H2,1-4H3;1H/t14-,16+,17-,18+,20-,21-,22+,24+,25-,26+,27-;/m0./s1
SMILES Code
O=C1[C@@]2([H])C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@@]([C@@]4([H])C(C3)=C(C)[C@@]5(O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)CC4)([H])C1.Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 16.0 34.48
Ethanol 1.0 2.15
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 464.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. An, J.-J., Zhou, J.-L., Li, H.-J., et al. Puqienine E: An angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis. Fitoterapia 81(3), 149-152 (2010). Chou, T. Q. (1947). Some minor alkaloids of Pei-Mu, Fritillaria roylei. Journal of the American Pharmaceutical Association (Scientific ed.), 36(7), 215-217.