MedKoo Cat#: 574163 | Name: Homovanillic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Homovanillic acid is a dopamine metabolite formed via deamination of dopamine by monoamine oxidase (MAO) to produce DOPAC followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

Chemical Structure

Homovanillic acid
Homovanillic acid
CAS#306-08-1

Theoretical Analysis

MedKoo Cat#: 574163

Name: Homovanillic acid

CAS#: 306-08-1

Chemical Formula: C9H10O4

Exact Mass: 182.0579

Molecular Weight: 182.17

Elemental Analysis: C, 59.34; H, 5.53; O, 35.13

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Homovanillic acid, HVA, NSC 16682, Vanilacetic Acid
IUPAC/Chemical Name
4-hydroxy-3-methoxy-benzeneacetic acid
InChi Key
QRMZSPFSDQBLIX-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)
SMILES Code
OC(CC1=CC(OC)=C(O)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Käenmaki, M., Tammimäki, A., Myöhänen, T., et al. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J. Neurochem. 114(6), 1745-1755 (2010). 2. Ruch, W., Cooper, P.H., and Baggiolini, M. Assay of H2O2 production by macrophages and neutrophils with homovanillic acid and horse-radish peroxidase. J. Immunol. Methods 63(3), 347-357 (1983).