Scopine HCl | CAS# 85700-55-6 | Metabolite

MedKoo Cat#: 574162 | Name: Scopine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scopine HCl is a metabolite of the muscarinic antagonist scopolamine. It reduces hyperphagia induced by the antipsychotics loxapine and chlorpromazine. When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil.

Chemical Structure

Scopine HCl

CAS#85700-55-6

Theoretical Analysis

MedKoo Cat#: 574162

Name: Scopine HCl

CAS#: 85700-55-6

Chemical Formula: C8H14ClNO2

Exact Mass: 0.0000

Molecular Weight: 191.66

Elemental Analysis: C, 50.14; H, 7.36; Cl, 18.50; N, 7.31; O, 16.70

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 220.00
250mg	USD 340.00
500mg	USD 530.00
1g	USD 750.00
5g	USD 1,150.00

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Synonym

Scopine Hydrochloride, Scopine HCl

IUPAC/Chemical Name

(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol hydrochloride

InChi Key

BBBRAOXIMQHVCR-YSJWXMLMSA-N

InChi Code

InChI=1S/C8H13NO2.ClH/c1-9-5-2-4(10)3-6(9)8-7(5)11-8;/h4-8,10H,2-3H2,1H3;1H/t4-,5-,6+,7-,8+;

SMILES Code

O[C@H]1C[C@H](N2C)[C@@H]3O[C@@H]3[C@H]2C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO and ethanol

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 ≥500 µM).

In vitro activity:

Results from this study suggest that scopine is a potential brain-targeting moiety for enhancing the brain uptake efficiency of chlorambucil. Reference: Bioconjug Chem. 2014 Nov 19;25(11):2046-54. https://pubmed.ncbi.nlm.nih.gov/25350514/

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	5.0	26.09
	Ethanol	1.0	5.22

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 191.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Wang X, Li J, Xu C, Li Y, Gong T, Sun X, Fu Y, He Q, Zhang Z. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014 Nov 19;25(11):2046-54. doi: 10.1021/bc5004108. Epub 2014 Nov 6. PMID: 25350514. 2. Écija P, Vallejo-López M, Uriarte I, Basterretxea FJ, Lesarri A, Fernández JA, Cocinero EJ. Scopine Isolated in the Gas Phase. Chemphyschem. 2016 Oct 5;17(19):3030-3034. doi: 10.1002/cphc.201600368. Epub 2016 Jul 28. PMID: 27338110.

In vitro protocol:

In vivo protocol:

To be determined

Liu TC. Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients. Asian Pac J Cancer Prev. 2014;15(16):6703-7. doi: 10.7314/apjcp.2014.15.16.6703. PMID: 25169512.