AES-350 | CAS#847249-57-4 | HDAC inhibitor

MedKoo Cat#: 408056 | Name: AES-350

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AES-350 is a potent and selective HDAC6 inhibitor. AES-350 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. AES-350 also demonstrated improved oral bioavailability compared to SAHA in mouse models. AES-350 exhibited an in vitro HDAC6 selectivity profile comparable to that of ricolinostat and citarinostat.

Chemical Structure

AES-350

CAS#847249-57-4

Theoretical Analysis

MedKoo Cat#: 408056

Name: AES-350

CAS#: 847249-57-4

Chemical Formula: C18H20N2O3

Exact Mass: 312.1474

Molecular Weight: 312.37

Elemental Analysis: C, 69.21; H, 6.45; N, 8.97; O, 15.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AES-350; AES 350; AES350;

IUPAC/Chemical Name

4-(tert-butyl)-N-(4-(hydroxycarbamoyl)phenyl)benzamide

InChi Key

FMOQHLZNJFXULZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H20N2O3/c1-18(2,3)14-8-4-12(5-9-14)16(21)19-15-10-6-13(7-11-15)17(22)20-23/h4-11,23H,1-3H3,(H,19,21)(H,20,22)

SMILES Code

CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.