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MedKoo Cat#: 533336 | Name: 3i-0777

Description:

WARNING: This product is for research use only, not for human or veterinary use.

3i-0777 is a novel GATA4-NKX2-5 transcriptional synergy activator, significantly enhancing the mechanical stretch-stimulated increase of the ANP mRNA levels.

Chemical Structure

3i-0777
3i-0777
CAS#878090-53-0

Theoretical Analysis

MedKoo Cat#: 533336

Name: 3i-0777

CAS#: 878090-53-0

Chemical Formula: C21H18ClN3O2S

Exact Mass: 411.0808

Molecular Weight: 411.90

Elemental Analysis: C, 61.24; H, 4.40; Cl, 8.61; N, 10.20; O, 7.77; S, 7.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
3i-0777; 3i 0777; 3i0777;
IUPAC/Chemical Name
N-(4-Chlorophenyl)-5-methyl-N-(4-methyl-4,5-dihydrothiazol-2-yl)-3-phenylisoxazole-4-carboxamide
InChi Key
GKELNWVZTJUVJN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18ClN3O2S/c1-13-12-28-21(23-13)25(17-10-8-16(22)9-11-17)20(26)18-14(2)27-24-19(18)15-6-4-3-5-7-15/h3-11,13H,12H2,1-2H3
SMILES Code
O=C(C1=C(C)ON=C1C2=CC=CC=C2)N(C3=CC=C(Cl)C=C3)C4=NC(C)CS4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
GATA4 belongs to the GATA protein family (GATA1–6) and is characterized by WGATAR-recognizing zinc-finger domains that mediate DNA binding and protein–protein interactions. Our previous work illustrated that the protein assembly between GATA4 and NKX2-5, which is a critical GATA4 cofactor, imposes a structural fold that is similar to that of the evolutionally conserved DNA binding domains of nuclear receptors. The significance of this particular protein–protein complex has been further validated by the co-occurrence of GATA4 and NKX2-5 in the binding site locations. (16) In addition to protein–protein interactions, the function of GATA4 is modulated through post-translational modifications. An increased GATA4 transcriptional activity has been shown in luciferase reporter assays with phosphorylated, acetylated, or sumoylated GATA4 protein. Therefore, the functional modulation of the GATA4 protein or the GATA4–NKX2-5 interaction could represent an innovative therapeutic approach for cardiac regeneration or other pathophysiological conditions. However, currently, there are no small molecule inhibitors or activators of GATA4 function except for one report describing inhibitors of GATA4 binding to DNA

Preparing Stock Solutions

The following data is based on the product molecular weight 411.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL