Zelkovamycin is a nucleoside antibiotic produced by Streptomyces species, exhibiting potent antibacterial activity against Gram-positive bacteria. Its mechanism of action involves inhibition of bacterial RNA synthesis by targeting RNA polymerase, disrupting transcription and ultimately preventing bacterial growth. The structural modifications in its nucleoside moiety enhance its binding affinity to the enzyme, leading to effective inhibition. Due to its unique mode of action, Zelkovamycin is a potential lead for developing new antibiotics to combat resistant bacterial strains.
MedKoo Cat#: 574160
Name: Zelkovamycin
CAS#: 221197-33-7
Chemical Formula: C36H45N9O9S
Exact Mass: 779.3061
Molecular Weight: 779.87
Elemental Analysis: C, 55.44; H, 5.82; N, 16.16; O, 18.46; S, 4.11
The following data is based on the product molecular weight 779.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
