MedKoo Cat#: 574159 | Name: Antibiotic PF 1052
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antibiotic PF 1052 is a fungal metabolite active against S. aureus, S. parvulus, and C. perfringens. It inhibits neutrophil migration, reduces pseudopodia formation, and induces rounding of neutrophils. Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils.

Chemical Structure

Antibiotic PF 1052
Antibiotic PF 1052
CAS#147317-15-5

Theoretical Analysis

MedKoo Cat#: 574159

Name: Antibiotic PF 1052

CAS#: 147317-15-5

Chemical Formula: C26H39NO4

Exact Mass: 429.2879

Molecular Weight: 429.60

Elemental Analysis: C, 72.69; H, 9.15; N, 3.26; O, 14.90

Price and Availability

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1mg USD 450.00 Back order
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Synonym
Antibiotic PF 1052
IUPAC/Chemical Name
(E)-5-(sec-butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione
InChi Key
NPWKEUKXVOMELT-XTQSDGFTSA-N
InChi Code
InChI=1S/C26H39NO4/c1-8-14(3)22-24(29)21(25(30)27(22)7)23(28)20-18(26(6)16(5)31-26)10-9-17-12-13(2)11-15(4)19(17)20/h9-10,13-20,22,28H,8,11-12H2,1-7H3/b23-21+
SMILES Code
CC1CC(C)C2C(C=CC(C3(C)C(C)O3)C2/C(O)=C4C(N(C)C(C(C)CC)C\4=O)=O)C1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 429.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Sasaki, T., Takagi, M., Yaguchi, M., et al. Novel antibiotic PF1052 and its manufacture with Phoma species. Jpn. Kokai Tokkyo Koho (1992). 2. Wang, X., Robertson, A.L., Li, J., et al. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis. Model Mech. 7(1), 163-169 (2014).