MedKoo Cat#: 574146 | Name: Roridin L2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Roridin L2 is a fungal metabolite.

Chemical Structure

Roridin L2
Roridin L2
CAS#85124-22-7

Theoretical Analysis

MedKoo Cat#: 574146

Name: Roridin L2

CAS#: 85124-22-7

Chemical Formula: C29H38O9

Exact Mass: 530.2516

Molecular Weight: 530.61

Elemental Analysis: C, 65.64; H, 7.22; O, 27.14

Price and Availability

Size Price Availability Quantity
1mg USD 350.00
5mg USD 950.00
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Related CAS #
No Data
Synonym
Roridin L2
IUPAC/Chemical Name
(2S,2'R,4'R,5'S,5a'R,9a'R)-5a'-(hydroxymethyl)-5',8'-dimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-4'-yl (2Z,4E)-7-hydroxy-6-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethoxy)octa-2,4-dienoate
InChi Key
JGIYRVDWRBKREW-JNMAXWDTSA-N
InChi Code
InChI=1S/C29H38O9/c1-18-8-10-28(16-30)23(12-18)37-24-14-22(27(28,3)29(24)17-36-29)38-25(32)7-5-4-6-21(19(2)31)34-11-9-20-13-26(33)35-15-20/h4-7,12-13,19,21-24,30-31H,8-11,14-17H2,1-3H3/b6-4+,7-5-/t19?,21?,22-,23-,24-,27-,28-,29+/m1/s1
SMILES Code
CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C(OCCC5=CC(OC5)=O)C(O)C)=O)([H])O2)(CO)CC1
Appearance
Solid powder
Purity
>70% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Roridin L2 possesses little in vitro or in vivo toxic activity.
In vitro activity:
To be determined
In vivo activity:
This article describes an optimized protocol for production and isolation of trichothecenes from S. chartarum cultures. The results demonstrate that while the macrocyclic satratoxin G was neurotoxic in vitro and in vivo, its biosynthetic precursor, RL2, was not. Reference: J Toxicol Environ Health A. 2009;72(20):1242-51. https://pubmed.ncbi.nlm.nih.gov/20077192/

Preparing Stock Solutions

The following data is based on the product molecular weight 530.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Islam Z, Shinozuka J, Harkema JR, Pestka JJ. Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. J Toxicol Environ Health A. 2009;72(20):1242-51. doi: 10.1080/15287390903129234. PMID: 20077192; PMCID: PMC2808125.
In vitro protocol:
To be determined
In vivo protocol:
1. Islam Z, Shinozuka J, Harkema JR, Pestka JJ. Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. J Toxicol Environ Health A. 2009;72(20):1242-51. doi: 10.1080/15287390903129234. PMID: 20077192; PMCID: PMC2808125.
Ulrich S, Gottschalk C, Biermaier B, Bahlinger E, Twarużek M, Asmussen S, Schollenberger M, Valenta H, Ebel F, Dänicke S. Occurrence of type A, B and D trichothecenes, zearalenone and stachybotrylactam in straw. Arch Anim Nutr. 2021 Apr;75(2):105-120. doi: 10.1080/1745039X.2021.1877075. Epub 2021 Feb 21. PMID: 33615927.