U 81749 | CAS#126103-94-4 | anti-HIV

MedKoo Cat#: 585357 | Name: U 81749

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 81749 is a peptide that inhibits recombinant HIV-1 protease in vitro and HIV-1 replication in human peripheral blood lymphocytes.

Chemical Structure

U 81749

CAS#126103-94-4

Theoretical Analysis

MedKoo Cat#: 585357

Name: U 81749

CAS#: 126103-94-4

Chemical Formula: C33H56N4O4

Exact Mass: 572.4302

Molecular Weight: 572.84

Elemental Analysis: C, 69.19; H, 9.85; N, 9.78; O, 11.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

U 81749; U81749; U-81749

IUPAC/Chemical Name

6-cyclohexyl-5-(3,3-dimethylbutanoylamino)-4-hydroxy-N-[3-methyl-1-oxo-1-(pyridin-2-ylmethylamino)pentan-2-yl]-2-propan-2-ylhexanamide

InChi Key

RLQUQIUJPBZNMI-UHFFFAOYSA-N

InChi Code

InChI=1S/C33H56N4O4/c1-8-23(4)30(32(41)35-21-25-16-12-13-17-34-25)37-31(40)26(22(2)3)19-28(38)27(18-24-14-10-9-11-15-24)36-29(39)20-33(5,6)7/h12-13,16-17,22-24,26-28,30,38H,8-11,14-15,18-21H2,1-7H3,(H,35,41)(H,36,39)(H,37,40)

SMILES Code

O=C(NC(C(C)CC)C(NCC1=NC=CC=C1)=O)C(C(C)C)CC(O)C(NC(CC(C)(C)C)=O)CC2CCCCC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 572.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Uhl D. [Therapeutic drugs--rarely causal therapy]. Med Monatsschr Pharm. 1990 May;13(5):129. German. PubMed PMID: 2192241. 2: A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Dis Markers. 1990 May-Jun;8(3):162-3. PubMed PMID: 2125537. 3: Two more attacks on HIV. Lancet. 1990 Feb 10;335(8685):345. PubMed PMID: 1967781. 4: McQuade TJ, Tomasselli AG, Liu L, Karacostas V, Moss B, Sawyer TK, Heinrikson RL, Tarpley WG. A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science. 1990 Jan 26;247(4941):454-6. PubMed PMID: 2405486.