U 93385 | CAS#147145-16-2 | bradycardic

MedKoo Cat#: 585355 | Name: U 93385

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 93385 is a 5-hydroxytryptamine (5-HT)1A receptor agonist that has bradycardic effects.

Chemical Structure

U 93385

CAS#147145-16-2

Theoretical Analysis

MedKoo Cat#: 585355

Name: U 93385

CAS#: 147145-16-2

Chemical Formula: C16H22N2O

Exact Mass: 258.1732

Molecular Weight: 258.37

Elemental Analysis: C, 74.38; H, 8.58; N, 10.84; O, 6.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

U 93385; U93385; U-93385

IUPAC/Chemical Name

(3aR,9bS)-3-propyl-1,2,3a,4,5,9b-hexahydrobenzo[e]indole-9-carboxamide

InChi Key

JSZBRMZCAIJCKB-TZMCWYRMSA-N

InChi Code

InChI=1S/C16H22N2O/c1-2-9-18-10-8-12-14(18)7-6-11-4-3-5-13(15(11)12)16(17)19/h3-5,12,14H,2,6-10H2,1H3,(H2,17,19)/t12-,14-/m1/s1

SMILES Code

O=C(C1=C2[C@]3([H])CCN(CCC)[C@]3([H])CCC2=CC=C1)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 258.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: McCall RB, Escandon NA, Harris LT, Clement ME. Rapid and long duration tolerance to the vagal bradycardic effects of 5-HT1A receptor agonists. Behav Brain Res. 1996;73(1-2):297-300. PubMed PMID: 8788523. 2: Haadsma-Svensson SR, Svensson K, Duncan N, Smith MW, Lin CH. C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability. J Med Chem. 1995 Feb 17;38(4):725-34. PubMed PMID: 7861420. 3: McCall RB, Escandon NA, Harris LT, Clement ME. Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. J Pharmacol Exp Ther. 1994 Nov;271(2):776-81. PubMed PMID: 7965796. 4: Lin CH, Haadsma-Svensson SR, Phillips G, McCall RB, Piercey MF, Smith MW, Svensson K, Carlsson A, Chidester CG, Von Voigtlander PF. Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability. J Med Chem. 1993 Jul 23;36(15):2208-18. PubMed PMID: 8340922.