U 71184 | CAS#101222-80-4 | anti-tumor

MedKoo Cat#: 585351 | Name: U 71184

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 71184 is an anti-tumor agent.

Chemical Structure

U 71184

CAS#101222-80-4

Theoretical Analysis

MedKoo Cat#: 585351

Name: U 71184

CAS#: 101222-80-4

Chemical Formula: C30H23N5O3

Exact Mass: 501.1801

Molecular Weight: 501.55

Elemental Analysis: C, 71.84; H, 4.62; N, 13.96; O, 9.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

U 71184; U71184; U-71184

IUPAC/Chemical Name

N-[2-[(12S)-3-Methyl-7-oxo-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-10-carbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide

InChi Key

KSEVSZOOMUWSRV-VITKDRCNSA-N

InChi Code

InChI=1S/C30H23N5O3/c1-15-13-31-27-24(36)11-25-30(26(15)27)12-18(30)14-35(25)29(38)23-10-17-8-19(6-7-21(17)34-23)32-28(37)22-9-16-4-2-3-5-20(16)33-22/h2-11,13,18,31,33-34H,12,14H2,1H3,(H,32,37)/t18-,30?/m1/s1

SMILES Code

O=C(C(N1)=CC2=C1C=CC=C2)NC3=CC4=C(NC(C(N(C[C@@]5([H])C6)C(C56C7=C8NC=C7C)=CC8=O)=O)=C4)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 501.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Gambari R, Bianchi N, Passadore M, Ambrosino P, Mongelli N, Cozzi P, Geroni C. Synthesis, cytotoxicity, antitumor activity and sequence selective binding of two pyrazole analogs structurally related to the antitumor agents U-71,184 and adozelesin. Anticancer Drug Des. 1997 Oct;12(7):555-76. PubMed PMID: 9365502. 2: Passadore M, Bianchi N, Feriotto G, Mischiati C, Rutigliano C, Gambari R. In vitro and in vivo binding of a CC-1065 analogue to human gene sequences: a polymerase-chain reaction study. Eur J Pharmacol. 1997 Jan 29;319(2-3):317-25. PubMed PMID: 9042607. 3: Kim DY, Shih DS, Cho DY, Swenson DH. Helix-stabilizing compounds CC-1065 and U-71,184 bind to RNA-DNA and DNA-DNA duplexes containing modified internucleotide linkages and stabilize duplexes against thermal melting. Antisense Res Dev. 1995 Spring;5(1):49-57. PubMed PMID: 7542048. 4: Mohamadi F, Spees MM, Staten GS, Marder P, Kipka JK, Johnson DA, Boger DL, Zarrinmayeh H. Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits. J Med Chem. 1994 Jan 21;37(2):232-9. PubMed PMID: 8295210. 5: Lee S, Inselburg J. In vitro sensitivity of Plasmodium falciparum to drugs that bind DNA or inhibit its synthesis. J Parasitol. 1993 Oct;79(5):780-2. PubMed PMID: 8410555. 6: Moy BC, Petzold GL, Badiner GJ, Kelly RC, Aristoff PA, Adams EG, Li LH, Bhuyan BK. Characterization of B16 melanoma cells resistant to the CC-1065 analogue U-71,184. Cancer Res. 1990 Apr 15;50(8):2485-92. PubMed PMID: 2317831. 7: Swenson DH, Petzold GL, Williams MG, Li LH, Prairie MD, Krueger WC. Evaluation of DNA binding characteristics of some CC-1065 analogs. Chem Biol Interact. 1988;67(3-4):199-213. PubMed PMID: 3191534. 8: Adams EG, Badiner GJ, Bhuyan BK. Effects of U-71,184 and several other CC-1065 analogues on cell survival and cell cycle of Chinese hamster ovary cells. Cancer Res. 1988 Jan 1;48(1):109-16. PubMed PMID: 2446739.