MB-0223 | CAS#2247732-89-2

MedKoo Cat#: 471037 | Name: MB-0223

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MB-0223 is a novel potent and selective STING agonist.

Chemical Structure

MB-0223

CAS#2247732-89-2

Theoretical Analysis

MedKoo Cat#: 471037

Name: MB-0223

CAS#: 2247732-89-2

Chemical Formula: C26H27N5OS

Exact Mass: 457.1936

Molecular Weight: 457.60

Elemental Analysis: C, 68.24; H, 5.95; N, 15.30; O, 3.50; S, 7.01

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 505.00	2 weeks

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Related CAS #

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Synonym

MB-0223, MB 0223, MB0223

IUPAC/Chemical Name

4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide

InChi Key

SWLKFZCOJAYAMJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H27N5OS/c1-19-14-24(25(32)28-22-9-7-20(8-10-22)21-6-5-11-27-15-21)31(16-19)17-23-18-33-26(29-23)30-12-3-2-4-13-30/h5-11,14-16,18H,2-4,12-13,17H2,1H3,(H,28,32)

SMILES Code

O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	45.8	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 457.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Mallat A. et al.; Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1; Biochem Biophys Res Commun. 2018 May 15;499(3):556-562. doi: 10.1016/j.bbrc.2018.03.189. Epub 2018 Apr 4.