MedKoo Cat#: 593154 | Name: YW1128
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YW1128 is an inhibitor of Wnt/β-catenin. It significantly decreases hepatic lipid accumulation.

Chemical Structure

YW1128
YW1128
CAS#2131223-64-6

Theoretical Analysis

MedKoo Cat#: 593154

Name: YW1128

CAS#: 2131223-64-6

Chemical Formula: C20H17N5O

Exact Mass: 343.1433

Molecular Weight: 343.39

Elemental Analysis: C, 69.96; H, 4.99; N, 20.40; O, 4.66

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
YW1128 ; YW 1128; YW-1128
IUPAC/Chemical Name
5-methyl-N-(quinolin-2-yl)-1-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide
InChi Key
SXZFICNOPPNYJM-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H17N5O/c1-13-7-3-6-10-17(13)25-14(2)19(23-24-25)20(26)22-18-12-11-15-8-4-5-9-16(15)21-18/h3-12H,1-2H3,(H,21,22,26)
SMILES Code
CC(C=CC=C1)=C1N2N=NC(C(NC(C=C3)=NC4=C3C=CC=C4)=O)=C2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 343.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Yang W, Li Y, Ai Y, Obianom ON, Guo D, Yang H, Sakamuru S, Xia M, Shu Y, Xue F. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 10. doi: 10.1021/acs.jmedchem.9b01252. [Epub ahead of print] PubMed PMID: 31769984.