Squalene | CAS# 111-02-4 | Steroid Precursor

MedKoo Cat#: 574139 | Name: Squalene

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Squalene is a biosynthetic precursor to all steroids. An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA. Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents.

Chemical Structure

Squalene

CAS#111-02-4

Theoretical Analysis

MedKoo Cat#: 574139

Name: Squalene

CAS#: 111-02-4

Chemical Formula: C30H50

Exact Mass: 410.3913

Molecular Weight: 410.73

Elemental Analysis: C, 87.73; H, 12.27

Price and Availability

Size	Price	Availability	Quantity
50g	USD 205.00
100g	USD 330.00

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Related CAS #

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Synonym

Spinacene, Squalene, trans-Squalene

IUPAC/Chemical Name

(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene

InChi Key

YYGNTYWPHWGJRM-AAJYLUCBSA-N

InChi Code

InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+

SMILES Code

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C

Appearance

Oil

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 410.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ram JPS, Ramakrishnan R, K PK, Singh S, R AK, Govindan S, Selvaraj R, Manikandan R. Phyto-safe in vitro regeneration and harnessing antimicrobial- resistant endophytes as bioinoculants for enhanced growth and secondary metabolites yield in Nilgirianthus ciliatus. BMC Plant Biol. 2024 Sep 19;24(1):872. doi: 10.1186/s12870-024-05582-8. PMID: 39294576; PMCID: PMC11411983. 2: Kamau SW, Ngugi MP, Mwitari PG, Njeru SN. Network pharmacology, molecular docking and experimental approaches of the anti-proliferative effects of Rhamnus prinoides ethyl-acetate extract in cervical cancer cells. Heliyon. 2024 Sep 2;10(17):e37324. doi: 10.1016/j.heliyon.2024.e37324. PMID: 39290290; PMCID: PMC11407055. 3: Karlsson Ø, Govus AD, McGawley K, Hanstock HG. Metabolic Phenotyping from Whole-Blood Responses to a Standardized Exercise Test May Discriminate for Physiological, Performance, and Illness Outcomes: A Pilot Study in Highly- Trained Cross-Country Skiers. Sports Med Open. 2024 Sep 18;10(1):99. doi: 10.1186/s40798-024-00770-0. PMID: 39289269; PMCID: PMC11408465. 4: Mahapatra B, Singh A, Banerjee A, Sirohi S, Singh S, Dubey VK, Singh RK. A squalene oil emulsified MPL-A and anti-CD200/CD300a antibodies adjuvanted whole- killed Leishmania vaccine provides durable immunity against L. donovani parasites. Vaccine. 2024 Sep 16;42(26):126373. doi: 10.1016/j.vaccine.2024.126373. Epub ahead of print. PMID: 39288578. 5: Wang J, Cheng Y, Fang L, Yang A, Luo F, Lu J, Ren J. Physicochemical properties, profile of volatiles, fatty acids, lipids and concomitants from four Kadsura coccinea seed oils. Food Chem X. 2024 Aug 28;23:101765. doi: 10.1016/j.fochx.2024.101765. PMID: 39280213; PMCID: PMC11402108. 6: Dong R, Leng T, Wang Y, Gan B, Yu Q, Xie J, Du Q, Zhu M, Chen Y. Full composition-wide association study identifies the chemical markers to distinguish different processed camellia oils: Integrating multi-targets with chemometrics. Food Chem. 2024 Sep 12;463(Pt 2):141217. doi: 10.1016/j.foodchem.2024.141217. Epub ahead of print. PMID: 39276554. 7: Zhang J, Gao W, Jahan I, Zhai R, Yao K, Yan J, Li P. The Cytotoxic Activity and Metabolic Profiling of Hyptis rhomboidea Mart. et Gal. Molecules. 2024 Sep 5;29(17):4216. doi: 10.3390/molecules29174216. PMID: 39275063; PMCID: PMC11396782. 8: Zhou Z, Gao P, Zhou Y, Wang X, Yin J, Zhong W, Reaney MJT. Comparative Analysis of Frying Performance: Assessing Stability, Nutritional Value, and Safety of High-Oleic Rapeseed Oils. Foods. 2024 Sep 1;13(17):2788. doi: 10.3390/foods13172788. PMID: 39272553; PMCID: PMC11394795. 9: Slimani WA, Albergamo A, Rando R, Nava V, Safi MO, Bensenane SMB, Lo Turco V, Benmahioul B, Di Bella G. Preliminary Evaluation of the Effect of Domestication on the Marketable and Nutritional Quality of B. aegyptiaca (L.) Delile Oil from Algeria. Foods. 2024 Aug 29;13(17):2752. doi: 10.3390/foods13172752. PMID: 39272520; PMCID: PMC11395238. 10: Yang T, Kubo S, Juntila DJ, Iwata Y, Tomita K, Hase Y, Oono Y, Araie H, Yoneda K, Maeda Y, Suzuki I. Aurantiochytrium mutant strains exhibiting different colony colors altered the contents of squalene. Biosci Biotechnol Biochem. 2024 Sep 13:zbae128. doi: 10.1093/bbb/zbae128. Epub ahead of print. PMID: 39271467. 11: Mochizuki T, Anzawa K, Bernales-Mendoza AM, Shimizu A. Case of tinea corporis caused by a terbinafine-sensitive Trichophyton indotineae strain in a Vietnamese worker in Japan. J Dermatol. 2024 Sep 13. doi: 10.1111/1346-8138.17463. Epub ahead of print. PMID: 39269204. 12: Zhang Y, Bejaoui M, Linh TN, Arimura T, Isoda H. A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo. Cell Commun Signal. 2024 Sep 11;22(1):437. doi: 10.1186/s12964-024-01813-5. PMID: 39261954; PMCID: PMC11389383. 13: Zhao YC, Li YF, Qiu L, Jin SZ, Shen YN, Zhang CH, Cui J, Wang TJ. SQLE-a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration. BMC Cancer. 2024 Sep 11;24(1):1133. doi: 10.1186/s12885-024-12897-0. PMID: 39261819; PMCID: PMC11389260. 14: Xiong Y, Lu G, Li H, He J, Fan S, Yan S, Zhang L, Jia H, Li M. Integrating QTL mapping and transcriptomics to decipher the genetic architecture of sterol metabolism in Brassica napus L. Hortic Res. 2024 Jul 24;11(9):uhae196. doi: 10.1093/hr/uhae196. PMID: 39257541; PMCID: PMC11384122. 15: Wang Y, Yang Z, Yuan B, He L, Han Y, Wang J, Wang X. Genome-wide identification of oxidosqualene cyclase genes regulating natural rubber in Taraxacum kok-saghyz. Planta. 2024 Sep 10;260(4):88. doi: 10.1007/s00425-024-04522-y. PMID: 39251530. 16: Rosik N, Preece JA, Fryer PJ, McRobbie I, Zhang ZJ. A review of artificial sebum formulations, their compositions, uses and physicochemical characteristics. Int J Cosmet Sci. 2024 Sep 9. doi: 10.1111/ics.13022. Epub ahead of print. PMID: 39246274. 17: Wang K, Yin M, Sun ML, Zhao Q, Ledesma-Amaro R, Ji XJ, Lin L. Engineering Yarrowia lipolytica for Efficient Synthesis of Geranylgeraniol. J Agric Food Chem. 2024 Sep 18;72(37):20568-20581. doi: 10.1021/acs.jafc.4c06749. Epub 2024 Sep 6. PMID: 39241196. 18: Craciun BF, Rosca I, Peptanariu D, Pinteala M. Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier. ChemMedChem. 2024 Sep 6:e202400432. doi: 10.1002/cmdc.202400432. Epub ahead of print. PMID: 39240546. 19: Bansal Y, Mujib A, Mamgain J, Syeed R, Mohsin M, Nafees A, Dewir YH, Mendler-Drienyovszki N. Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L. Front Plant Sci. 2024 Aug 22;15:1433634. doi: 10.3389/fpls.2024.1433634. PMID: 39239200; PMCID: PMC11374661. 20: Eichhorn E, Schilling B, Bombrun A, Schroeder F. Sustainable (-)-Ambrox Production: Chemistry Meets Biocatalysis. Chimia (Aarau). 2024 Aug 21;78(7-8):468-475. doi: 10.2533/chimia.2024.468. PMID: 39221842.