Butikacin | CAS#59733-86-7 | antibiotic

MedKoo Cat#: 585327 | Name: Butikacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Butikacin, also known as UK 18892, is a semisynthetic aminoglycoside antibiotic.

Chemical Structure

Butikacin

CAS#59733-86-7

Theoretical Analysis

MedKoo Cat#: 585327

Name: Butikacin

CAS#: 59733-86-7

Chemical Formula: C22H45N5O12

Exact Mass: 571.3065

Molecular Weight: 571.63

Elemental Analysis: C, 46.23; H, 7.94; N, 12.25; O, 33.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Butikacin; UK-18,892; UK 18892; UK18892; UK-18892

IUPAC/Chemical Name

(2R,3R,4S,5S,6R)-2-[(1R,2S,3S,4R,6S)-6-amino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[[(2S)-4-amino-2-hydroxybutyl]amino]-2-hydroxycyclohexyl]oxy-6-(aminomethyl)oxane-3,4,5-triol

InChi Key

OCFOTEIMZBKQFS-DGMGPCKZSA-N

InChi Code

InChI=1S/C22H45N5O12/c23-2-1-7(29)5-27-9-3-8(25)19(38-22-17(34)16(33)14(31)10(4-24)36-22)18(35)20(9)39-21-15(32)12(26)13(30)11(6-28)37-21/h7-22,27-35H,1-6,23-26H2/t7-,8-,9+,10+,11+,12-,13+,14+,15+,16-,17+,18-,19+,20-,21+,22+/m0/s1

SMILES Code

O[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](NC[C@@H](O)CCN)C[C@@H]2N)O[C@H](CN)[C@@H](O)[C@@H]1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 571.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Carter AJ. Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs. Antimicrob Agents Chemother. 1979 Sep;16(3):362-5. PubMed PMID: 507791; PubMed Central PMCID: PMC352861. 2: Le Goffic F, Capmau ML, Tangy F, Caminade E. Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes? J Antibiot (Tokyo). 1980 Aug;33(8):895-9. PubMed PMID: 7000739. 3: Coleman MW, Kinns M, Sewell MJ. 13C-NMR studies on 1-N-[(S)-4-amino-2-hydroxybutyl]kanamycin A (butikacin) and related aminoglycosides. J Antibiot (Tokyo). 1979 Apr;32(4):355-60. PubMed PMID: 468723. 4: Trollfors B. Quantitative studies on antibiotic nephrotoxicity. Scand J Infect Dis Suppl. 1980;Suppl 21:1-46. PubMed PMID: 7003703. 5: Trollfors B, Alestig K, Ahlmén J, Norrby R. Effect on the renal function of UK 18892. J Antimicrob Chemother. 1980 Sep;6(5):685-7. PubMed PMID: 7410292.