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MedKoo Cat#: 585325 | Name: UH 301

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UH 301 is a 5-HT1A receptor antagonist.

Chemical Structure

UH 301
UH 301
CAS#127126-21-0

Theoretical Analysis

MedKoo Cat#: 585325

Name: UH 301

CAS#: 127126-21-0

Chemical Formula: C16H24FNO

Exact Mass: 265.1842

Molecular Weight: 265.37

Elemental Analysis: C, 72.42; H, 9.12; F, 7.16; N, 5.28; O, 6.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
UH 301; UH301; UH-301
IUPAC/Chemical Name
1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, (S)-
InChi Key
FNKBVTBXFLSTPB-LBPRGKRZSA-N
InChi Code
InChI=1S/C16H24FNO/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17/h7-8,12,19H,3-6,9-11H2,1-2H3/t12-/m0/s1
SMILES Code
OC1=C2C[C@@H](N(CCC)CCC)CCC2=C(F)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 265.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yan H, Yu H, Lewander T. An integrative pharmacokinetic and pharmacodynamic study of the 5-HT1A receptor antagonist (S)-UH-301 in the rat. Eur Neuropsychopharmacol. 2002 Apr;12(2):101-10. PubMed PMID: 11872325. 2: Nomikos GG, Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 decreases dopamine release in the rat nucleus accumbens and striatum. J Neural Transm (Vienna). 1996;103(5):541-54. PubMed PMID: 8811500. 3: Ahlenius S, Henriksson I, Magnusson O, Salmi P. In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):15-9. PubMed PMID: 10082223. 4: Dahlin M, Björk E. Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. Int J Pharm. 2000 Feb 15;195(1-2):197-205. PubMed PMID: 10675697. 5: Darmani NA, Reeves SL. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacol Biochem Behav. 1996 Sep;55(1):1-10. PubMed PMID: 8870031. 6: Moreau JL, Griebel G, Jenck F, Martin JR, Widmer U, Haefely WE. Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys. Brain Res Bull. 1992 Dec;29(6):901-4. PubMed PMID: 1473022. 7: Johansson CE, Meyerson BJ, Hacksell U. The novel 5-HT1A receptor antagonist (S)-UH-301 antagonizes 8-OH-DPAT-induced effects on male as well as female rat copulatory behaviour. Eur J Pharmacol. 1991 Sep 4;202(1):81-7. PubMed PMID: 1838499. 8: Arborelius L, Nomikos GG, Hertel P, Salmi P, Grillner P, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1996 May;353(6):630-40. PubMed PMID: 8738296. 9: Arborelius L, Höök BB, Hacksell U, Svensson TH. The 5-HT1A receptor antagonist (S)-UH-301 blocks the qR)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. J Neural Transm Gen Sect. 1994;96(3):179-86. PubMed PMID: 7826569. 10: Arborelius L, Chergui K, Murase S, Nomikos GG, Höök BB, Chouvet G, Hacksell U, Svensson TH. The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn Schmiedebergs Arch Pharmacol. 1993 Apr;347(4):353-62. PubMed PMID: 8510763. 11: Nomikos GG, Arborelius L, Svensson TH. The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. Eur J Pharmacol. 1992 Jun 17;216(3):373-8. PubMed PMID: 1425929. 12: Björk L, Fredriksson A, Hacksell U, Lewander T. Effects of (R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of (R)-8-OH-DPAT-induced effects. Eur Neuropsychopharmacol. 1992 Jun;2(2):141-7. PubMed PMID: 1385999. 13: Stevens KE, O'Neill HC, Rose GM, Luthman J. The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats. Amino Acids. 2006 Nov;31(4):365-75. Epub 2006 Aug 2. PubMed PMID: 16868646. 14: Koprowska M, Krotewicz M, Romaniuk A, Strzelczuk M, Wieczorek M. Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats. Acta Neurobiol Exp (Wars). 2002;62(2):63-74. Erratum in: Acta Neurobiol Exp (Warsz). 2002;62(4):283.. PubMed PMID: 12201034. 15: Björk L, Lindgren S, Hacksell U, Lewander T. (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat. Eur J Pharmacol. 1991 Jul 9;199(3):367-70. PubMed PMID: 1833212. 16: Sylte I, Edvardsen O, Dahl SG. Molecular modelling of UH-301 and 5-HT(1a) receptor interactions. Protein Eng. 1996 Feb;9(2):149-60. PubMed PMID: 9005436. 17: Arborelius L, Nomikos GG, Grillner P, Hertel P, Höök BB, Hacksell U, Svensson TH. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):157-65. PubMed PMID: 7477438. 18: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. PubMed PMID: 19837141. 19: Meneses A, Hong E. 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats. Neurobiol Learn Mem. 1999 Mar;71(2):207-18. PubMed PMID: 10082640. 20: Griebel G, Rodgers RJ, Perrault G, Sanger DJ. Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists. Psychopharmacology (Berl). 1999 May;144(2):121-30. PubMed PMID: 10394992.

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