Synonym
C16-GHK, C16-GK-3, Pal-GHK, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-1
IUPAC/Chemical Name
N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine
InChi Key
BYUQATUKPXLFLZ-UIOOFZCWSA-N
InChi Code
InChI=1S/C30H54N6O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27(37)33-22-28(38)35-26(20-24-21-32-23-34-24)29(39)36-25(30(40)41)17-15-16-19-31/h21,23,25-26H,2-20,22,31H2,1H3,(H,32,34)(H,33,37)(H,35,38)(H,36,39)(H,40,41)/t25-,26-/m0/s1
SMILES Code
O=C(N[C@H](C(O)=O)CCCCN)[C@@H](NC(CNC(CCCCCCCCCCCCCCC)=O)=O)CC1=CN=CN1
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Palmitoyl tripeptide-1 is a fatty acid modified polypeptide.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
30.0 |
51.83 |
| DMSO |
10.0 |
17.28 |
| Ethanol |
30.0 |
51.83 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
578.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1. Lintner, K., and Peschard, O. Biologically active peptides: From a laboratory bench curiosity to a functional skin care product. Int. J. Cosmet. Sci. 22(3), 207-218 (2000).
2. Zhang, H., Sun, J., Xin, X., et al. Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system. J. Colloid. Interface Sci. 467, 43-50 (2016).
3. Castelletto, V., Hamley, I.W., Whitehouse, C., et al. Self-assembly of palmitoyl lipopeptides used in skin care products. Langmuir 29(29), 9149-9155 (2013).
4. Chirita, R.-I., Chaimbbault, P., Archambault, J.-C., et al. Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics. Anal. Chim. Acta 641(1-2), 95-100 (2009).
Park, S. I., An, G. M., Kim, M. G., Heo, S. H., & Shin, M. S. (2019). Enhancement of skin permeation of wrinkle improvement peptides GHKs using liposomes containing skin penetrating peptides. Journal of the Korean Applied Science and Technology, 36(3), 853-865.
Mortazavi, S. M., Vadoud, S. A. M., & Moghimi, H. R. (2024). Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective. BioImpacts.
