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MedKoo Cat#: 582049 | Name: Tetracaine hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tetracaine hydrochloride is a potent local anesthetic of the ester type used for surface and spinal anesthesia.

Chemical Structure

Tetracaine hydrochloride
CAS#136-47-0

Theoretical Analysis

MedKoo Cat#: 582049

Name: Tetracaine hydrochloride

CAS#: 136-47-0

Chemical Formula: C15H25ClN2O2

Exact Mass: 300.1600

Molecular Weight: 300.83

Elemental Analysis: C, 59.89; H, 8.38; Cl, 11.78; N, 9.31; O, 10.64

Price and Availability

Size Price Availability Quantity
5g USD 210.00
25g USD 370.00
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Related CAS #
No Data
Synonym
Tetracaine hydrochloride; Amethocaine hydrochloride; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid; Tetracaine HCl.
IUPAC/Chemical Name
2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride
InChi Key
PPWHTZKZQNXVAE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
SMILES Code
c1(C(OCCN(C)C)=O)ccc(NCCCC)cc1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang N, Jin F, Liu W, Dang S, Wang Y, Yan Y, Wu G. 1%Tetracaine hydrochloride injection pure solution aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia for bronchoscopy: A randomized controlled trial. Clin Respir J. 2019 Nov 20. doi: 10.1111/crj.13110. [Epub ahead of print] PubMed PMID: 31746542. 2: Zhao LM, Gan L, Zhang Y. Matrix effect-free on-line pass-through cleanup procedure for the fast determination of local anesthetic drug by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Nov 1;1130-1131:121831. doi: 10.1016/j.jchromb.2019.121831. Epub 2019 Oct 21. PubMed PMID: 31669630. 3: Wang X, Nie F, Ye N, Liu X, Yang S. The feasibility study of transnasopharyngeal esophagus echocardiography in the ultrasonic diagnosis. Cardiovasc Ultrasound. 2019 Mar 1;17(1):4. doi: 10.1186/s12947-019-0154-2. PubMed PMID: 30823923; PubMed Central PMCID: PMC6397502. 4: Kleris RS, Keswani A, Lugar P. The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old Woman With Macular Degeneration. Allergy Rhinol (Providence). 2018 May 1;9:2152656718763385. doi: 10.1177/2152656718763385. eCollection 2018 Jan-Dec. PubMed PMID: 29977647; PubMed Central PMCID: PMC6028157. 5: Fornells E, Fuguet E, Mañé M, Ruiz R, Box K, Bosch E, Ràfols C. Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method. Eur J Pharm Sci. 2018 May 30;117:227-235. doi: 10.1016/j.ejps.2018.02.025. Epub 2018 Feb 23. PubMed PMID: 29481859. 6: Ridruejo C, Centellas F, Cabot PL, Sirés I, Brillas E. Electrochemical Fenton-based treatment of tetracaine in synthetic and urban wastewater using active and non-active anodes. Water Res. 2018 Jan 1;128:71-81. doi: 10.1016/j.watres.2017.10.048. Epub 2017 Oct 23. PubMed PMID: 29091806. 7: Waldman N, Winrow B, Densie I, Gray A, McMaster S, Giddings G, Meanley J. An Observational Study to Determine Whether Routinely Sending Patients Home With a 24-Hour Supply of Topical Tetracaine From the Emergency Department for Simple Corneal Abrasion Pain Is Potentially Safe. Ann Emerg Med. 2018 Jun;71(6):767-778. doi: 10.1016/j.annemergmed.2017.02.016. Epub 2017 May 5. PubMed PMID: 28483289. 8: Ethington J, Goldmeier D, Gaynes BI. Exponential Decay Metrics of Topical Tetracaine Hydrochloride Administration Describe Corneal Anesthesia Properties Mechanistically. Cornea. 2017 Mar;36(3):363-366. doi: 10.1097/ICO.0000000000001125. PubMed PMID: 28060026. 9: Venturi F, Blocker T, Dees DD, Madsen R, Brinkis J. Corneal anesthetic effect and ocular tolerance of 3.5% lidocaine gel in comparison with 0.5% aqueous proparacaine and 0.5% viscous tetracaine in normal canines. Vet Ophthalmol. 2017 Sep;20(5):405-410. doi: 10.1111/vop.12440. Epub 2016 Dec 15. PubMed PMID: 27981712. 10: Lajtai A, Mayer M, Lakatos Á, Porpáczy Z, Miseta A. Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse? J Forensic Sci. 2016 Mar;61(2):573-575. doi: 10.1111/1556-4029.13010. Epub 2016 Feb 1. PubMed PMID: 27404634. 11: Pang X, Fan TJ. Cytotoxic effect and possible mechanisms of Tetracaine on human corneal epithelial cells in vitro. Int J Ophthalmol. 2016 Apr 18;9(4):497-504. doi: 10.18240/ijo.2016.04.04. eCollection 2016. PubMed PMID: 27162719; PubMed Central PMCID: PMC4853342. 12: Jichao S, Cuida M, Mingxing C, Yunyun W, Dongdong Z. Oral dyclonine hydrochloride mucilage versus tetracaine spray in electronic flexible laryngoscopy: A prospective, randomized controlled trial. Am J Otolaryngol. 2016 Mar-Apr;37(2):169-71. doi: 10.1016/j.amjoto.2015.12.005. Epub 2015 Dec 9. PubMed PMID: 26954876. 13: Ciancio SG, Marberger AD, Ayoub F, Garlapo DA, Pantera EA Jr, Pantera CT, Al-Mubarak S, Sobieraj BD, He DY, Myneni SR. Comparison of 3 intranasal mists for anesthetizing maxillary teeth in adults: A randomized, double-masked, multicenter phase 3 clinical trial. J Am Dent Assoc. 2016 May;147(5):339-347.e1. doi: 10.1016/j.adaj.2015.11.009. Epub 2016 Feb 15. PubMed PMID: 26892312. 14: Teixeira RS, Cova TF, Silva SM, Oliveira R, do Vale ML, Marques EF, Pais AA, Veiga FJ. Novel serine-based gemini surfactants as chemical permeation enhancers of local anesthetics: A comprehensive study on structure-activity relationships, molecular dynamics and dermal delivery. Eur J Pharm Biopharm. 2015 Jun;93:205-13. doi: 10.1016/j.ejpb.2015.02.024. Epub 2015 Mar 6. PubMed PMID: 25748796. 15: Teixeira RS, Cova TF, Silva SM, Oliveira R, Araújo MJ, Marques EF, Pais AA, Veiga FJ. Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics. Int J Pharm. 2014 Oct 20;474(1-2):212-22. doi: 10.1016/j.ijpharm.2014.08.002. Epub 2014 Aug 7. Erratum in: Int J Pharm. 2014 Nov 20;475(1-2):633. PubMed PMID: 25108047. 16: Waldman N, Densie IK, Herbison P. Topical tetracaine used for 24 hours is safe and rated highly effective by patients for the treatment of pain caused by corneal abrasions: a double-blind, randomized clinical trial. Acad Emerg Med. 2014 Apr;21(4):374-82. doi: 10.1111/acem.12346. PubMed PMID: 24730399. 17: Zhang L, Tanabe K, Yanagidate F, Kawasaki Y, Chen G, Dohi S, Iida H. Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons. Eur J Pharmacol. 2014 Jul 5;734:132-6. doi: 10.1016/j.ejphar.2014.03.048. Epub 2014 Apr 12. PubMed PMID: 24726558. 18: Ge CG, Jiang J, Jiang Q, Liu C, Hu ZL, Liang PH, Zhang WL. Holmium:YAG laser ablation combined intraurethral fluorouracil perfusion as treatment option for intraurethral Condyloma acuminata in men. Minerva Urol Nefrol. 2014 Mar;66(1):77-81. PubMed PMID: 24721943. 19: Bezáková Z, Stankovičová M. [Alkalimetric titrations of salts of organic bases in the Pharmacopoeia]. Ceska Slov Farm. 2013 Dec;62(6):264-9. Czech. PubMed PMID: 24393115. 20: Douet JY, Michel J, Regnier A. Degree and duration of corneal anesthesia after topical application of 0.4% oxybuprocaine hydrochloride ophthalmic solution in ophthalmically normal dogs. Am J Vet Res. 2013 Oct;74(10):1321-6. doi: 10.2460/ajvr.74.10.1321. PubMed PMID: 24066916.

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