U46,195 | CAS#141490-47-3 | activator

MedKoo Cat#: 585316 | Name: U46,195

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U46,195 stimulates the production of tissue-type plasminogen activator, and is a PAF antagonist.

Chemical Structure

U46,195

CAS#141490-47-3

Theoretical Analysis

MedKoo Cat#: 585316

Name: U46,195

CAS#: 141490-47-3

Chemical Formula: C17H13ClN4O

Exact Mass: 324.0778

Molecular Weight: 324.77

Elemental Analysis: C, 62.87; H, 4.03; Cl, 10.92; N, 17.25; O, 4.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

U46,195; U 46,195; U-46,195; U 46195; U46195; U-46195

IUPAC/Chemical Name

3-(8-chloro-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-6-yl)phenol

InChi Key

GGQZNQSJWZEGBR-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13ClN4O/c1-10-20-21-16-9-19-17(11-3-2-4-13(23)7-11)14-8-12(18)5-6-15(14)22(10)16/h2-8,23H,9H2,1H3

SMILES Code

OC1=CC=CC(C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C24)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 324.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Torr SR, Haskel EJ, VonVoigtlander PF, Bergmann SR, Abendschein DR. Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor. J Am Coll Cardiol. 1991 Dec;18(7):1804-10. PubMed PMID: 1960333. 2: Kooistra T, Toet K, Kluft C, VonVoigtlander PF, Ennis MD, Aiken JW, Boadt JA, Erickson LA. Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells. Biochem Pharmacol. 1993 Jul 6;46(1):61-7. PubMed PMID: 8347138.