THS is a novel AChE inhibitor, inducing creased hippocampal H2S levels, reducing mRNA expression of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β, increasing synapse-associated proteins (synaptophysin and postsynaptic density protein 95), and improving cognitive and locomotor activity in AD mice.
MedKoo Cat#: 533231
Name: THS
CAS#: N/A
Chemical Formula: C22H29N3OS2
Exact Mass: 415.1752
Molecular Weight: 415.61
Elemental Analysis: C, 63.58; H, 7.03; N, 10.11; O, 3.85; S, 15.43
The following data is based on the product molecular weight 415.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
