HTH-02-006 ameliorates YAP(S127A)-induced hepatomegaly, and reduces MYPT1(S445) phosphorylation in the same tissues. HTH-02-006 delays the outgrowth of YAP-induced HuCCT-1 xenograft tumors in nude mice, supposedly through NUAK2 inhibition. HTH-02-006 is a reversible small-molecule inhibitor of the Hippo pathway kinase, NUAK2. It can be used as a tool compound to investigate the role of NUAK2 in cancer and other Hippo pathway-associated biological processes. HTH-02-006 is a derivative of the prototype NUAK inhibitor WZ4003. It is active in vivo.
MedKoo Cat#: 465029
Name: HTH-02-006
CAS#: Unknown
Chemical Formula: C25H29IN6O3
Exact Mass: 588.1346
Molecular Weight: 588.45
Elemental Analysis: C, 51.03; H, 4.97; I, 21.57; N, 14.28; O, 8.16
The following data is based on the product molecular weight 588.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
