CVM-6-139-1 blocked HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells, and blocked tunicamycin-induced cell death with an EC50 of 0.403 uM. CVM-6-139-1 blocked p-HIPK2 [S359/T360] in primary spinal motor neurons and protected >60% of these neurons from tunicamycin- and SOD1G93A-induced cell death.
MedKoo Cat#: 465022
Name: CVM-6-139-1
CAS#: 1365986-44-2 (free base)
Chemical Formula: C18H17N5O3S
Exact Mass: 383.1052
Molecular Weight: 383.43
Elemental Analysis: C, 56.39; H, 4.47; N, 18.27; O, 12.52; S, 8.36
The following data is based on the product molecular weight 383.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
