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MedKoo Cat#: 585305 | Name: Flutrimazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flutrimazole is a wide-spectrum antifungal used in the treatment of superficial mycoses of the skin.

Chemical Structure

Flutrimazole
Flutrimazole
CAS#119006-77-8

Theoretical Analysis

MedKoo Cat#: 585305

Name: Flutrimazole

CAS#: 119006-77-8

Chemical Formula: C22H16F2N2

Exact Mass: 346.1282

Molecular Weight: 346.38

Elemental Analysis: C, 76.29; H, 4.66; F, 10.97; N, 8.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Flutrimazole; UR-4056; UR4056; UR 4056
IUPAC/Chemical Name
1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-
InChi Key
QHMWCHQXCUNUAK-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H
SMILES Code
FC1=CC=C(C(N2C=CN=C2)(C3=CC=CC=C3F)C4=CC=CC=C4)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 346.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J. Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group. Dermatology. 1995;190(4):295-300. PubMed PMID: 7655109. 2: Noguera J, Lerís E, Algueró M, Boncompte E, Izquierdo I; Grupo de trabajo flutrimazol gel. [Review of the clinical efficacy of flutrimazole gel in the treatment of dandruff and/or seborrheic dermatitis.]. Rev Iberoam Micol. 1998 Mar;15(1):28-32. Spanish. PubMed PMID: 17655401. 3: Binet O, Soto-Melo J, Delgadillo J, Videla S, Izquierdo I, Forn J. Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a randomized, multicentre, double-blind, comparative clinical trial with 1% clotrimazole cream. Flutrimazole Study Group. Mycoses. 1994 Nov-Dec;37(11-12):455-9. PubMed PMID: 7659137. 4: del Palacio A, Cuétara S, Pérez A, Garau M, Calvo T, Sánchez-Alor G. Topical treatment of dermatophytosis and cutaneous candidosis with flutrimazole 1% cream: double-blind, randomized comparative trial with ketoconazole 2% cream. Mycoses. 1999;42(11-12):649-55. PubMed PMID: 10680442. 5: Rigopoulos D, Gregoriou S, Kontochristopoulos G, Ifantides A, Katsambas A. Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial. Mycoses. 2007 May;50(3):193-5. PubMed PMID: 17472615. 6: Velasco A, Román C, Aragüés M, Noguera X, Ventura C, Lerís E. [Comparison of the efficacy of 1% flutrimazole cream twice a day with 1% flutrimazole cream once a day for the treatment of superficial dermatophytoses]. Rev Iberoam Micol. 2002 Sep;19(3):169-72. Spanish. PubMed PMID: 12825997. 7: del Palacio, Cuétara S, Izquierdo I, Videla S, Delgadillo J, Boncompte E, Rodríguez Noriega A. A double-blind, randomized comparative trial: flutrimazole 1% solution versus bifonazole 1% solution once daily in dermatomycoses. Mycoses. 1995 Sep-Oct;38(9-10):395-403. PubMed PMID: 8569816. 8: García Rafanell J, Dronda MA, Merlos M, Forn J, Torres JM, Zapatero MI, Basi N. In vitro and in vivo studies with flutrimazole, a new imidazole derivative with antifungal activity. Arzneimittelforschung. 1992 Jun;42(6):836-40. PubMed PMID: 1418042. 9: Pereda J, Noguera X, Boncompte E, Algueró M, Izquierdo I. Efficacy of flutrimazole 1% powder in the treatment of tinea pedis. Mycoses. 2003 Apr;46(3-4):126-31. PubMed PMID: 12870201. 10: Vericat ML, García Rafanell J, Forn J, Casadesús A, Alumá J, Zapatero J. Toxicity studies with flutrimazole. Arzneimittelforschung. 1992 Jun;42(6):841-6. PubMed PMID: 1418043. 11: Conte L, Ramis J, Mis R, Vilageliu J, Basi N, Forn J. Pharmacokinetic study of [14C]flutrimazole after oral and intravenous administration in dogs. Comparison with clotrimazole. Arzneimittelforschung. 1992 Jun;42(6):854-8. PubMed PMID: 1418045. 12: Van Gerven F, Odds FC. The anti-Malassezia furfur activity in vitro and in experimental dermatitis of six imidazole antifungal agents: bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole. Mycoses. 1995 Sep-Oct;38(9-10):389-93. PubMed PMID: 8569815. 13: del Palacio A, Sanz F, Sánchez-Alor G, Garau M, Calvo MT, Boncompte E, Algueró M, Pontes C, Gómez de la Cámara A. Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream. Mycoses. 2000 Oct;43(9-10):355-65. PubMed PMID: 11105539. 14: Ramis J, Conte L, Segado X, Forn J, Lauroba J, Calpena A, Escribano E, Domenech J. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997 Oct;47(10):1139-44. PubMed PMID: 9368709. 15: Izquierdo I, Bayes M, Jané J, Alomar A, Forn J. Local and systemic tolerance of flutrimazole skin creams following single and repeated topical application in healthy volunteers. Arzneimittelforschung. 1992 Jun;42(6):859-60. PubMed PMID: 1418046. 16: Conte L, Ramis J, Mis R, Forn J, Vilaró S, Reina M, Vilageliu J, Basi N. Percutaneous absorption and skin distribution of [14C]flutrimazole in mini-pigs. Arzneimittelforschung. 1992 Jun;42(6):847-53. PubMed PMID: 1418044. 17: Yim SM, Ko JH, Lee YW, Kim HW, Lee JY, Kim NI, Kye YC, Park KC, Choi JH, Lee KH, Kim MN, Kim KJ, Ro YS, Ahn KJ. Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial. Mycoses. 2010 Nov;53(6):522-9. doi: 10.1111/j.1439-0507.2009.01738.x. PubMed PMID: 19558428. 18: John B, Wood SG, Ramis J, Izquierdo I, Forn J. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittelforschung. 1998 May;48(5):512-7. PubMed PMID: 9638320. 19: Merlos M, Vericat ML, García-Rafanell J, Forn J. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996 Jan;45(1):20-5. PubMed PMID: 8821774. 20: Shen L, Liu SJ, Zhang NS, Dai GL, Zou C, Li CY, Chen XH, Ju WZ. Sensitive and selective LC-MS/MS assay for quantitation of flutrimazole in human plasma. Eur Rev Med Pharmacol Sci. 2017 Jun;21(12):2964-2969. PubMed PMID: 28682419.