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MedKoo Cat#: 574122 | Name: Complanatuside
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Complanatuside is a flavonoid glucoside that inhibits nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells.

Chemical Structure

Complanatuside
CAS#116183-66-5

Theoretical Analysis

MedKoo Cat#: 574122

Name: Complanatuside

CAS#: 116183-66-5

Chemical Formula: C28H32O16

Exact Mass: 624.1690

Molecular Weight: 624.55

Elemental Analysis: C, 53.85; H, 5.16; O, 40.99

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Complanatuside; Complanatoside; Complanatoside-A; Complanatoside A
IUPAC/Chemical Name
5-hydroxy-7-methoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4H-chromen-4-one
InChi Key
KKPKUPKKMALLKG-QDYVESOYSA-N
InChi Code
InChI=1S/C28H32O16/c1-39-12-6-13(31)17-14(7-12)41-25(26(20(17)34)44-28-24(38)22(36)19(33)16(9-30)43-28)10-2-4-11(5-3-10)40-27-23(37)21(35)18(32)15(8-29)42-27/h2-7,15-16,18-19,21-24,27-33,35-38H,8-9H2,1H3/t15-,16-,18-,19-,21+,22+,23-,24-,27-,28+/m1/s1
SMILES Code
COC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)=C(C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)O5)=O)C5=C1
Appearance
A crystalline solid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 624.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang X, Xu X, Wu P, Wu M, Gan L, Jin J, Wu R, Liu W, Zhang K, Li D, Zheng X. Complanatuside alleviates inflammatory cell damage induced by pro-inflammatory cytokines in skin keratinocytes. Front Chem. 2022 Aug 10;10:909651. doi: 10.3389/fchem.2022.909651. PMID: 36034662; PMCID: PMC9399639. 2: Yao YF, Lin CZ, Liu FL, Zhang RJ, Zhang QY, Huang T, Zou YS, Wang MQ, Zhu CC. Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS. Molecules. 2018 Dec 25;24(1):71. doi: 10.3390/molecules24010071. PMID: 30585251; PMCID: PMC6337141. 3: L Bello M, Mendes GEM, Silva ACR, Faria RX. Virtual screening indicates potential inhibitors of the P2X7 receptor. Comput Biol Med. 2023 Aug 3;164:107299. doi: 10.1016/j.compbiomed.2023.107299. Epub ahead of print. PMID: 37552915. 4: Kuo JC, Zhang LJ, Huang HT, Liaw CC, Lin ZH, Liu M, Kuo YH. Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen. Molecules. 2020 Oct 16;25(20):4762. doi: 10.3390/molecules25204762. PMID: 33081333; PMCID: PMC7587559. 5: Chen J, Zhu F, Pan M, Liu Q, Chen L, Tao Y. An emerging strategy for tracing the anti-erectile dysfunction components of raw and salt-processed semens of Astragali Complanati by combinatory liquid chromatography-mass spectrometry- based quantitative analysis, efficacy assessment on impotent rats, and partial least squares regression. J Sep Sci. 2022 Jun;45(11):1952-1959. doi: 10.1002/jssc.202200019. Epub 2022 Apr 15. PMID: 35384303. 6: Ng YF, Tang PC, Sham TT, Lam WS, Mok DK, Chan SW. Semen Astragali Complanati: an ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2014 Aug 8;155(1):39-53. doi: 10.1016/j.jep.2014.06.013. Epub 2014 Jun 13. PMID: 24933224. 7: Li N, Liu Y, Cao Y, Wei Z, Pang L, Wang J. Quantification of complanatoside A in rat plasma using LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 2016 Jun;30(6):888-93. doi: 10.1002/bmc.3624. Epub 2015 Oct 28. PMID: 26393341. 8: Zhang JJ, Yan XL, Zhang YJ, Wang YP, Zhang QJ, Zeng FY, Li W, Ou LN. [Determination of complanatoside A in semen Astragali complanati by HPLC]. Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(8):600-2. Chinese. PMID: 16011285. 9: Chen MH, Liu FS. [Studies on chemical constituents of Astragalus complanatus R. Brown. II]. Yao Xue Xue Bao. 1988 Mar;23(3):218-20. Chinese. PMID: 3421111.