Synonym
U-92032; U92032; U 92032
IUPAC/Chemical Name
2,4,6-Cycloheptatrien-1-one, 7-((4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)methyl)-2-((2-hydroxyethyl)amino)-4-(1-methylethyl)-
InChi Key
UVPCKMJVJLKETQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H35F2N3O2/c1-21(2)24-3-4-25(30(37)28(19-24)33-13-18-36)20-34-14-16-35(17-15-34)29(22-5-9-26(31)10-6-22)23-7-11-27(32)12-8-23/h3-12,19,21,29,36H,13-18,20H2,1-2H3,(H,33,37)
SMILES Code
O=C1C(NCCO)=CC(C(C)C)=CC=C1CN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
507.63
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Porcello DM, Smith SD, Huguenard JR. Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol. 2003 Jan;89(1):177-85. PubMed PMID: 12522170.
2: Avery RB, Johnston D. Ca2+ channel antagonist U-92032 inhibits both T-type Ca2+ channels and Na+ channels in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1997 Feb;77(2):1023-8. PubMed PMID: 9065866.
3: Ito C, Im WB, Takagi H, Takahashi M, Tsuzuki K, Liou SY, Kunihara M. U-92032, a T-type Ca2+ channel blocker and antioxidant, reduces neuronal ischemic injuries. Eur J Pharmacol. 1994 May 23;257(3):203-10. PubMed PMID: 8088342.
4: Lakhe M, Furukawa Y, Yonezawa T, Nagashima Y, Hirose M, Chiba S. Negative chronotropic and inotropic effects of U-92032, a novel T-type Ca2+ channel blocker, on the isolated, blood-perfused dog atrium. Jpn J Pharmacol. 1996 Aug;71(4):333-5. PubMed PMID: 8886931.
5: Xu X, Lee KS. A selective blocker for rested T-type Ca++ channels in guinea pig atrial cells. J Pharmacol Exp Ther. 1994 Mar;268(3):1135-42. PubMed PMID: 8138927.
6: N'Gouemo P, Rittenhouse AR. Biophysical and pharmacological characterization of voltage-sensitive calcium currents in neonatal rat inferior colliculus neurons. Neuroscience. 2000;96(4):753-65. PubMed PMID: 10727793.
7: Goto Y, Kassell NF, Hiramatsu K, Hong SC, Soleau SW, Lee KS. Effects of two dual-function compounds, U92798 and U92032, on transient focal ischemia in rats. Neurosurgery. 1994 Feb;34(2):332-7; discussion 337-8. PubMed PMID: 8177395.
