MedKoo Cat#: 585277 | Name: T-82

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-82 is an acetylcholinesterase inhibitor that may ameliorate the impairment of memory induced by acetylcholinergic dysfunction.

Chemical Structure

T-82
T-82
CAS#38455-99-1

Theoretical Analysis

MedKoo Cat#: 585277

Name: T-82

CAS#: 38455-99-1

Chemical Formula: C31H36ClN3O5S

Exact Mass: 597.2064

Molecular Weight: 598.16

Elemental Analysis: C, 62.25; H, 6.07; Cl, 5.93; N, 7.03; O, 13.37; S, 5.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
T-82; T82; T 82
IUPAC/Chemical Name
3,4,5-Trimethoxybenzoic acid, 2-(4-(3-(3-chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
InChi Key
KZAJTVRKNKAXAG-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H36ClN3O5S/c1-37-26-19-22(20-27(38-2)30(26)39-3)31(36)40-18-17-34-15-13-33(14-16-34)11-6-12-35-24-7-4-5-8-28(24)41-29-21-23(32)9-10-25(29)35/h4-5,7-10,19-21H,6,11-18H2,1-3H3
SMILES Code
O=C(OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC(Cl)=CC=C24)CC1)C5=CC(OC)=C(OC)C(OC)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 598.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Isoma K, Ishikawa M, Ohta M, Ogawa Y, Hasegawa H, Kohda T, Kamei J. Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Jpn J Pharmacol. 2002 Feb;88(2):206-12. PubMed PMID: 11928722. 2: Creasy SA, Rogers RJ, Byard TD, Kowalsky RJ, Jakicic JM. Energy Expenditure During Acute Periods of Sitting, Standing, and Walking. J Phys Act Health. 2016 Jun;13(6):573-8. doi: 10.1123/jpah.2015-0419. Epub 2015 Dec 21. PubMed PMID: 26693809. 3: Isomae K, Morimoto S, Hasegawa H, Morita K, Kamei J. Effects of T-82, a novel acetylcholinesterase inhibitor, on impaired learning and memory in passive avoidance task in rats. Eur J Pharmacol. 2003 Mar 28;465(1-2):97-103. PubMed PMID: 12650838. 4: Suzuki K, Takahara M, Shintani Y, Tanaka A, Soga Y, Yamaoka T, Tosaka A, Sasaki S, Kawasaki D, Tsuchiya T, Kozuki A, Iida O. Retrospective Multicenter Comparison of S.M.A.R.T. CONTROL and MISAGO Stents in Treatment of Femoropopliteal Lesions. J Vasc Interv Radiol. 2016 Nov;27(11):1642-1649. doi: 10.1016/j.jvir.2016.05.042. Epub 2016 Aug 24. PubMed PMID: 27567999. 5: Tak EJ, Kim PS, Hyun DW, Kim HS, Lee JY, Kang W, Sung H, Shin NR, Kim MS, Whon TW, Bae JW. Phenotypic and Genomic Properties of Brachybacterium vulturis sp. nov. and Brachybacterium avium sp. nov. Front Microbiol. 2018 Aug 7;9:1809. doi: 10.3389/fmicb.2018.01809. eCollection 2018. PubMed PMID: 30131788; PubMed Central PMCID: PMC6090031. 6: Xue Y, Nie L, Zhou Z, Tian H, Yan J, Wu X, Cheng L. Historical and future emission of hazardous air pollutants (HAPs) from gas-fired combustion in Beijing, China. Environ Sci Pollut Res Int. 2017 Jul;24(20):16946-16957. doi: 10.1007/s11356-017-9260-6. Epub 2017 Jun 3. PubMed PMID: 28577146. 7: Shen T, Zheng QQ, Shen J, Li QS, Song XH, Luo HB, Hong CY, Yao K. Effects of Adipose-derived Mesenchymal Stem Cell Exosomes on Corneal Stromal Fibroblast Viability and Extracellular Matrix Synthesis. Chin Med J (Engl). 2018 Mar 20;131(6):704-712. doi: 10.4103/0366-6999.226889. PubMed PMID: 29521294; PubMed Central PMCID: PMC5865317. 8: Carlos RV, de Boer HD, Torres ML, Carmona MJ. The effect of prior tetanic stimulation on train-of-four monitoring in paediatric patients: A randomised open-label controlled trial. Eur J Anaesthesiol. 2017 Mar;34(3):163-168. doi: 10.1097/EJA.0000000000000558. PubMed PMID: 27828786. 9: Asken BM, Clugston JR, Snyder AR, Bauer RM. Baseline Neurocognitive Performance and Clearance for Athletes to Return to Contact. J Athl Train. 2017 Jan;52(1):51-57. doi: 10.4085/1062-6050-51.12.27. Epub 2016 Dec 1. PubMed PMID: 27905859; PubMed Central PMCID: PMC5293518. 10: Mao Y, Wang C, Meng F, Kong J, Cao S, Jiang Y, Wang W, Hua D. Polymorphisms in the ICOS/CD28-ICOSL pathway are related to capecitabine-based chemotherapy response in advanced colon cancer patients. Mol Immunol. 2018 Apr;96:78-82. doi: 10.1016/j.molimm.2018.02.017. Epub 2018 Mar 5. PubMed PMID: 29505962. 11: Holmgren S, Hjorth E, Schultzberg M, Lärksäter M, Frenkel D, Tysen-Bäckström AC, Aarsland D, Freund-Levi Y. Neuropsychiatric symptoms in dementia-a role for neuroinflammation? Brain Res Bull. 2014 Sep;108:88-93. doi: 10.1016/j.brainresbull.2014.09.003. Epub 2014 Sep 16. PubMed PMID: 25224917. 12: Cliff MA, Stanich K, Lu R, Hampson CR. Use of descriptive analysis and preference mapping for early-stage assessment of new and established apples. J Sci Food Agric. 2016 Apr;96(6):2170-83. doi: 10.1002/jsfa.7334. Epub 2015 Aug 7. PubMed PMID: 26171961. 13: Marin-Urquiza A, Ferreira JP, Van Biesen D. Athletic identity and self-esteem among active and retired Paralympic athletes. Eur J Sport Sci. 2018 Jul;18(6):861-871. doi: 10.1080/17461391.2018.1462854. Epub 2018 Apr 17. PubMed PMID: 29663863. 14: Poorpezeshk N, Ghoreishi SK, Bayat M, Pouriran R, Yavari M. Early Low-Level Laser Therapy Improves the Passive Range of Motion and Decreases Pain in Patients with Flexor Tendon Injury. Photomed Laser Surg. 2018 Oct;36(10):530-535. doi: 10.1089/pho.2018.4458. PubMed PMID: 30300099. 15: Horvath C, Szonyi L, Mold K. Preventive effect of riboflavin and ATP on the teratogenic effects of the phenothiazine derivative T-82. Teratology. 1976 Oct;14(2):167-70. PubMed PMID: 982312. 16: Crane PB, Oles KS, Kennedy-Malone L. Beta-blocker medication usage in older women after myocardial infarction. J Am Acad Nurse Pract. 2006 Oct;18(10):463-70. PubMed PMID: 16999711. 17: Lick S, Kröckel L, Wibberg D, Winkler A, Blom J, Goesmann A, Kalinowski J. Pseudomonas bubulae sp. nov., isolated from beef. Int J Syst Evol Microbiol. 2019 Oct 17. doi: 10.1099/ijsem.0.003751. [Epub ahead of print] PubMed PMID: 31622235. 18: Maddison R, Gemming L, Monedero J, Bolger L, Belton S, Issartel J, Marsh S, Direito A, Solenhill M, Zhao J, Exeter DJ, Vathsangam H, Rawstorn JC. Quantifying Human Movement Using the Movn Smartphone App: Validation and Field Study. JMIR Mhealth Uhealth. 2017 Aug 17;5(8):e122. doi: 10.2196/mhealth.7167. PubMed PMID: 28818819; PubMed Central PMCID: PMC5579324. 19: Kanaji T, Okamura T, Osaki K, Kuroiwa M, Shimoda K, Hamasaki N, Niho Y. A common genetic polymorphism (46 C to T substitution) in the 5'-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level. Blood. 1998 Mar 15;91(6):2010-4. PubMed PMID: 9490684. 20: Mattar L, Farran N, Abi Kharma J, Zeeni N. Movie violence acutely affects food choices in young adults. Eat Behav. 2019 Apr;33:7-12. doi: 10.1016/j.eatbeh.2019.02.002. Epub 2019 Feb 10. PubMed PMID: 30771596.