M-89 is a highly potent and specific menin inhibitor. M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
MedKoo Cat#: 533207
Name: M-89 HCl
CAS#: M-89 HCl,
Chemical Formula: C37H49Cl2N5O4S
Exact Mass: 657.3349
Molecular Weight: 730.79
Elemental Analysis: C, 60.81; H, 6.76; Cl, 9.70; N, 9.58; O, 8.76; S, 4.39
The following data is based on the product molecular weight 730.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
