Tsushimycin | CAS#11054-63-0 | antibiotic

MedKoo Cat#: 585266 | Name: Tsushimycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tsushimycin is a peptide antibiotic that exhibits antitrypanosomal activity.

Chemical Structure

Tsushimycin

CAS#11054-63-0

Theoretical Analysis

MedKoo Cat#: 585266

Name: Tsushimycin

CAS#: 11054-63-0

Chemical Formula: C59H93N13O20

Exact Mass: 1303.6660

Molecular Weight: 1304.46

Elemental Analysis: C, 54.32; H, 7.19; N, 13.96; O, 24.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tsushimycin

IUPAC/Chemical Name

(3S)-4-[[(3S,7S,13S,16R,22S,28S,31S,34R)-16-(1-aminoethyl)-31-(1-carboxyethyl)-22,28-bis(carboxymethyl)-4-methyl-2,6,12,15,18,21,24,27,30,33-decaoxo-13-propan-2-yl-1,5,11,14,17,20,23,26,29,32-decazatricyclo[32.4.0.07,11]octatriacontan-3-yl]amino]-3-[[(Z)-12-methyltridec-3-enoyl]amino]-4-oxobutanoic acid

InChi Key

BYWOWQCRVFUOLF-AQZAFBPESA-N

InChi Code

InChI=1S/C59H93N13O20/c1-30(2)19-14-12-10-8-9-11-13-15-22-40(73)64-37(27-45(80)81)52(84)70-49-34(7)63-53(85)39-21-18-24-72(39)57(89)46(31(3)4)68-56(88)48(33(6)60)67-42(75)29-62-50(82)35(25-43(76)77)65-41(74)28-61-51(83)36(26-44(78)79)66-55(87)47(32(5)59(91)92)69-54(86)38-20-16-17-23-71(38)58(49)90/h13,15,30-39,46-49H,8-12,14,16-29,60H2,1-7H3,(H,61,83)(H,62,82)(H,63,85)(H,64,73)(H,65,74)(H,66,87)(H,67,75)(H,68,88)(H,69,86)(H,70,84)(H,76,77)(H,78,79)(H,80,81)(H,91,92)/b15-13-/t32?,33?,34?,35-,36-,37-,38+,39-,46-,47-,48+,49-/m0/s1

SMILES Code

O=C(O)C[C@H](NC(C/C=C\CCCCCCCC(C)C)=O)C(N[C@@H](C(C)NC([C@]1([H])CCCN1C([C@H](C(C)C)NC([C@@H](C(N)C)NC(CNC([C@H](CC(O)=O)NC(CNC([C@H](CC(O)=O)NC([C@H](C(C(O)=O)C)N2)=O)=O)=O)=O)=O)=O)=O)=O)C(N3CCCC[C@]3([H])C2=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,304.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harrington JM. Antimicrobial peptide killing of African trypanosomes. Parasite Immunol. 2011 Aug;33(8):461-9. doi: 10.1111/j.1365-3024.2011.01294.x. Review. PubMed PMID: 21517904; PubMed Central PMCID: PMC3138831. 2: Ishiyama A, Otoguro K, Iwatsuki M, Namatame M, Nishihara A, Nonaka K, Kinoshita Y, Takahashi Y, Masuma R, Shiomi K, Yamada H, Omura S. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. J Antibiot (Tokyo). 2009 Jun;62(6):303-8. doi: 10.1038/ja.2009.32. Epub 2009 May 1. Erratum in: J Antibiot (Tokyo). 2009 Jun;62(6):343. Iwatsuki, Masahito [corrected to Iwatsuki, Masato]. PubMed PMID: 19407848. 3: Bunkóczi G, Vértesy L, Sheldrick GM. Structure of the lipopeptide antibiotic tsushimycin. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1160-4. Epub 2005 Jul 20. PubMed PMID: 16041082. 4: Elbein AD. Inhibitors of the biosynthesis and processing of N-linked oligosaccharides. CRC Crit Rev Biochem. 1984;16(1):21-49. Review. PubMed PMID: 6232113. 5: Elbein AD. The effect of tsushimycin on the synthesis of lipid-linked saccharides in aorta. Biochem J. 1981 Feb 1;193(2):477-84. PubMed PMID: 7305944; PubMed Central PMCID: PMC1162629. 6: Shoji J, Otsuka H. Studies on tsushimycin. II. The structures of constituent fatty acids. J Antibiot (Tokyo). 1969 Oct;22(10):473-9. PubMed PMID: 5350503. 7: Shoji JI, Kozuki S, Okamoto S, Sakazaki R, Otsuka H. Studies on tsushimycin. I. Isolation and characterization of an acidic acylpeptide containing a new fatty acid. J Antibiot (Tokyo). 1968 Jul;21(7):439-43. PubMed PMID: 5708315.