MedKoo Cat#: 574090 | Name: ICAAc
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICAAc is a solvatochromic fluorescent pH probe. As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications.

Chemical Structure

ICAAc
ICAAc
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 574090

Name: ICAAc

CAS#: NONE

Chemical Formula: C14H9N3

Exact Mass: 219.0796

Molecular Weight: 219.25

Elemental Analysis: C, 76.70; H, 4.14; N, 19.17

Price and Availability

Size Price Availability Quantity
5mg USD 275.00 2 Weeks
10mg USD 500.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
3-amino-6-Isocyanoacridine, ICAAc
IUPAC/Chemical Name
6-isocyanoacridin-3-amine
InChi Key
GXXTUSOSNDNJFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H9N3/c1-16-12-5-3-10-6-9-2-4-11(15)7-13(9)17-14(10)8-12/h2-8H,15H2
SMILES Code
NC1=CC2=C(C=C1)C=C3C(C=C(C=C3)[N+]#[C-])=N2
Appearance
A crystalline solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, water, dioxane, and hexane
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO, water, dioxane, or hexane
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Emission: abs/em = 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous buffer Excitation: 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively

Preparing Stock Solutions

The following data is based on the product molecular weight 219.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).