Panaxatriol | CAS# 32791-84-7 | Sapogenin

MedKoo Cat#: 574082 | Name: Panaxatriol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Panaxatriol is a sapogenin that has antiproliferative, cardioprotective, and antidiabetic properties. It inhibits the proliferation of DU15 prostate cancer cells and induces apoptosis by increasing production of reactive oxygen species (ROS) and decreasing the mitochondrial membrane potential. Panaxatriol reduces ischemia and reperfusion-induced myocardial dysfunction, increases left ventricular developed pressure (LVDevP) and glutathione (GSH) levels, and decreases cardiac lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) levels in rats when administered for seven consecutive days prior to injury. Dietary administration of panaxatriol (0.2% for 6 weeks) decreases fasting blood glucose levels in KKAy insulin-resistant mice.

Chemical Structure

Panaxatriol

CAS#32791-84-7

Theoretical Analysis

MedKoo Cat#: 574082

Name: Panaxatriol

CAS#: 32791-84-7

Chemical Formula: C30H52O4

Exact Mass: 476.3866

Molecular Weight: 476.74

Elemental Analysis: C, 75.58; H, 10.99; O, 13.42

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 450.00
50mg	USD 650.00
100mg	USD 900.00

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Related CAS #

No Data

Synonym

NSC 308880, Panaxatriol

IUPAC/Chemical Name

(3S,5R,6R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-((R)-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol

InChi Key

QFJUYMMIBFBOJY-UXZRXANASA-N

InChi Code

InChI=1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1

SMILES Code

CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])C[C@@H](O)[C@@]4([H])[C@@]3(C)CC[C@]4([H])[C@]5(C)OC(C)(C)CCC5

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.

In vitro activity:

The results indicated that panaxatriol exerts dosedependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol was 30 μM. Panaxatriol was found to exert its anticancer activity through induction of apoptosis. The apoptosis of DU-15 cancer cells was prompted by ROSmediated alterations in mitochondrial membrane potential. Additionally, panaxatriol induced sub-G1 cell cycle arrest and suppressed the DU-15 cell migration ability in a concentration-dependent manner. Reference: J BUON. 2018 Jan-Feb;23(1):200-204. https://pubmed.ncbi.nlm.nih.gov/29552784/

In vivo activity:

Forty-five inbred albino mice were separated randomly into 3 groups: control group, radiation group, and radiation + PT (panaxatriol) group (200 mg/kg/d, 3 weeks). The numbers of peripheral blood cells and bone marrow CD34+ cells, and the expression of GM-CSF in the radiation group were lower than in the control group. After treatment with PT, the numbers of peripheral blood cells and CD34+ cells, and the expression of GM-CSF increased significantly. Reference: Saudi Med J. 2007 Dec;28(12):1791-5. https://pubmed.ncbi.nlm.nih.gov/18060204/

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	20.98
	DMSO	41.0	86.00
	Ethanol	10.0	20.98
	Ethanol:PBS (pH 7.2) (1:5)	0.2	0.34

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 476.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Yu R, Zhang Y, Xu Z, Wang J, Chen B, Jin H. Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest. J BUON. 2018 Jan-Feb;23(1):200-204. PMID: 29552784. 2. Takamura Y, Makanae Y, Ato S, Yoshii N, Kido K, Nomura M, Uchiyama A, Shiozawa N, Fujita S. Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle. Nutr Res. 2016 Nov;36(11):1193-1201. doi: 10.1016/j.nutres.2016.09.002. Epub 2016 Sep 13. PMID: 27865617. 3. Liu FY, Wang JN, Yu SD, Wang B, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5. PMID: 18060204.

In vitro protocol:

In vivo protocol:

1. Takamura Y, Makanae Y, Ato S, Yoshii N, Kido K, Nomura M, Uchiyama A, Shiozawa N, Fujita S. Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle. Nutr Res. 2016 Nov;36(11):1193-1201. doi: 10.1016/j.nutres.2016.09.002. Epub 2016 Sep 13. PMID: 27865617. 2. Liu FY, Wang JN, Yu SD, Wang B, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5. PMID: 18060204.

1: Wang X, Ma Y, Zuo C, Zhao Z, Ma R, Wang L, Fang Y, Zhang Y, Wu X. Discovery and Characterization of Panaxatriol as a Novel Thrombin Inhibitor from Panax notoginseng Using a Combination of Computational and Experimental Approaches. Planta Med. 2024 Aug;90(10):801-809. doi: 10.1055/a-2339-2720. Epub 2024 Jun 5. PMID: 38838717. 2: Li Y, Luo B, Lin X, Bai D, Li L, Gao D, Li X, Zhong X, Wei Y, Yang L, Zhu X, Han L, Tian H, Zhang R, Wang P. 20(R)-Panaxatriol enhances METTL3-mediated m6A modification of STUB1 to inhibit autophagy and exert antitumor effects in Triple-Negative Breast Cancer cells. Phytomedicine. 2024 Jul 25;130:155537. doi: 10.1016/j.phymed.2024.155537. Epub 2024 Mar 20. PMID: 38823344. 3: Lee YY, Oh Y, Seo MS, Seo MG, Han JE, Kim KT, Park JK, Kim SD, Park SJ, Kwak D, Rhee MH. The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo. J Ginseng Res. 2023 Sep;47(5):638-644. doi: 10.1016/j.jgr.2023.03.003. Epub 2023 Apr 14. PMID: 37720569; PMCID: PMC10499584. 4: Zhang JJ, Hu RY, Chen KC, Liu YB, Hou YY, Zhang YZ, Feng ZM, Chen RX, Zheng YN, Liu S, Li W. 20(S)-protopanaxatriol inhibited D-galactose-induced brain aging in mice via promoting mitochondrial autophagy flow. Phytother Res. 2023 Jul;37(7):2827-2840. doi: 10.1002/ptr.7779. Epub 2023 Apr 10. PMID: 37037488. 5: Shang JH, Qiao YJ, Zhu HT, Wang D, Yang CR, Zhang YJ. Discovery of nontriterpenoids from the rot roots of Panax notoginseng with cytotoxicity and their molecular docking study and experimental validation. RSC Adv. 2023 Apr 6;13(16):11037-11043. doi: 10.1039/d3ra00720k. PMID: 37033442; PMCID: PMC10077343. 6: Yao H, He Q, Huang C, Wei S, Gong Y, Li X, Liu W, Xu Z, Wu H, Zheng C, Gao Y. Corrigendum to "Panaxatriol saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation" [Free Radic. Biol. Med. 190 (2022) 264-275]. Free Radic Biol Med. 2023 Jun;202:34. doi: 10.1016/j.freeradbiomed.2023.03.023. Epub 2023 Mar 28. Erratum for: Free Radic Biol Med. 2022 Sep;190:264-275. doi: 10.1016/j.freeradbiomed.2022.08.016. PMID: 36996686. 7: Wu C, Wang Y, Sun H. Targeted and untargeted metabolomics reveals deep analysis of drought stress responses in needles and roots of Pinus taeda seedlings. Front Plant Sci. 2023 Jan 31;13:1031466. doi: 10.3389/fpls.2022.1031466. PMID: 36798806; PMCID: PMC9927248. 8: Wu F, Lai S, Fu D, Liu J, Wang C, Feng H, Liu J, Li Z, Li P. Neuroprotective Effects and Metabolomics Study of Protopanaxatriol (PPT) on Cerebral Ischemia/Reperfusion Injury In Vitro and In Vivo. Int J Mol Sci. 2023 Jan 16;24(2):1789. doi: 10.3390/ijms24021789. PMID: 36675303; PMCID: PMC9861888. 9: Wang J, Wei F, Wang Y, Liu Q, He R, Huang Y, Wei K, Xie X, Zhang M. Exploring the quality markers and mechanism of Bushen Huoxue Prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy. J Ethnopharmacol. 2023 Apr 24;306:116131. doi: 10.1016/j.jep.2022.116131. Epub 2023 Jan 4. PMID: 36610675. 10: Dai L, Zhang Y, Jiang Y, Chen K. Panax notoginseng preparation plus aspirin versus aspirin alone on platelet aggregation and coagulation in patients with coronary heart disease or ischemic stroke: A meta-analysis of randomized controlled trials. Front Pharmacol. 2022 Dec 7;13:1015048. doi: 10.3389/fphar.2022.1015048. PMID: 36569332; PMCID: PMC9768032. 11: Yao H, He Q, Huang C, Wei S, Gong Y, Li X, Liu W, Xu Z, Wu H, Zheng C, Gao Y. Panaxatriol saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation. Free Radic Biol Med. 2022 Sep;190:264-275. doi: 10.1016/j.freeradbiomed.2022.08.016. Epub 2022 Aug 14. Erratum in: Free Radic Biol Med. 2023 Jun;202:34. doi: 10.1016/j.freeradbiomed.2023.03.023. PMID: 35977659. 12: Zhu T, Wan Q. Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury. Chin J Traumatol. 2023 Jan;26(1):20-26. doi: 10.1016/j.cjtee.2022.06.008. Epub 2022 Jul 3. PMID: 35922249; PMCID: PMC9912185. 13: Zhang JJ, Chen KC, Zhou Y, Wei H, Qi MH, Wang Z, Zheng YN, Chen RX, Liu S, Li W. Evaluating the effects of mitochondrial autophagy flux on ginsenoside Rg2 for delaying D-galactose induced brain aging in mice. Phytomedicine. 2022 Sep;104:154341. doi: 10.1016/j.phymed.2022.154341. Epub 2022 Jul 16. PMID: 35870376. 14: Yao H, Xie Q, He Q, Zeng L, Long J, Gong Y, Li X, Li X, Liu W, Xu Z, Wu H, Zheng C, Gao Y. Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia- Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity. Oxid Med Cell Longev. 2022 May 27;2022:9626703. doi: 10.1155/2022/9626703. PMID: 35669855; PMCID: PMC9166985. 15: Madhi I, Kim JH, Shin JE, Kim Y. Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia. Mol Med Rep. 2021 Oct;24(4):698. doi: 10.3892/mmr.2021.12337. Epub 2021 Aug 9. PMID: 34368872; PMCID: PMC8365412. 16: Yildiz-Ozturk E, Saglam-Metiner P, Yesil-Celiktas O. Lung carcinoma spheroids embedded in a microfluidic platform. Cytotechnology. 2021 Jun;73(3):457-471. doi: 10.1007/s10616-021-00470-7. Epub 2021 Apr 22. PMID: 34149177; PMCID: PMC8167023. 17: Zhu JH, Xu JD, Zhou SS, Zhang XY, Zhou J, Kong M, Mao Q, Zhu H, Li SL. Differences in Intestinal Metabolism of Ginseng Between Normal and Immunosuppressed Rats. Eur J Drug Metab Pharmacokinet. 2021 Jan;46(1):93-104. doi: 10.1007/s13318-020-00645-1. PMID: 32894450. 18: Cheng Y, Li R, Lin Z, Chen F, Dai J, Zhu Z, Chen L, Zhao Y. Structure- activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127364. doi: 10.1016/j.bmcl.2020.127364. Epub 2020 Jun 24. PMID: 32738969. 19: Li C, Fan C, Zhao J, Di M, Sui C, Han L, Hu L. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. 2020 Dec;43(6):2109-2118. doi: 10.1007/s10753-020-01278-x. PMID: 32725513. 20: Wang P, Song D, Wan D, Li L, Mei W, Li X, Han L, Zhu X, Yang L, Cai Y, Zhang R. Ginsenoside panaxatriol reverses TNBC paclitaxel resistance by inhibiting the IRAK1/NF-κB and ERK pathways. PeerJ. 2020 Jun 3;8:e9281. doi: 10.7717/peerj.9281. PMID: 32547883; PMCID: PMC7275687.