Synonym
Tzc 5665; Tzc5665; Tzc-5665
IUPAC/Chemical Name
2-Butenedioic acid (Z)-, monoethyl ester, compd. with 4-chloro-2-(3-((1,1-dimethyl-2-((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)amino)ethyl)amino)-2-hydroxypropoxy)benzonitrile (1:1)
InChi Key
TZXOVBAUUXGKJG-QGAMPUOQSA-N
InChi Code
InChI=1S/C25H30ClN5O3.C6H8O4/c1-16-10-23(33)30-31-24(16)17-5-8-20(9-6-17)28-15-25(2,3)29-13-21(32)14-34-22-11-19(26)7-4-18(22)12-27;1-2-10-6(9)4-3-5(7)8/h4-9,11,16,21,28-29,32H,10,13-15H2,1-3H3,(H,30,33);3-4H,2H2,1H3,(H,7,8)/b;4-3-
SMILES Code
O=C(OCC)/C=C\C(O)=O.N#CC1=CC=C(Cl)C=C1OCC(O)CNC(C)(C)CNC2=CC=C(C(C(C)C3)=NNC3=O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
628.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Araki S, Uematsu T, Nagashima S, Matsuzaki T, Gotanda K, Ochiai H, Hashimoto H, Nakashima M. Cardiac and hemodynamic effects of TZC-5665, a novel pyridazinone derivative, and its metabolite in humans and dogs. Gen Pharmacol. 1997 Apr;28(4):545-53. PubMed PMID: 9147023.
2: Seki T, Kanada A, Nakao T, Shiraiwa M, Asano H, Miyazawa K, Ishimori T, Minami N, Shibata K, Yasuda K. Studies on agents with vasodilator and beta-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665. Chem Pharm Bull (Tokyo). 1998 Jan;46(1):84-96. PubMed PMID: 9468640.
3: Ishimori T, Gotanda K, Sasaki T, Shinbo A, Asano H, Miyazawa K, Miyasaka K. Cardiac effects of the novel pyridazinone derivative 6-[4-[2-[3-(5-chloro-2-cyanophenoxy)-2-hydroxypropylamino]- 2- methylpropylamino]phenyl]-4,5-dihydro-5-methyl-3(2H) pyridazinone monoethyl maleate and its metabolite in isolated heart preparations of guinea pigs and dogs. Arzneimittelforschung. 1994 May;44(5):583-8. PubMed PMID: 7912931.
4: Sugioka M, Ito M, Masuoka H, Ichikawa K, Konishi T, Tanaka T, Nakano T. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):284-93. PubMed PMID: 7824045.
