MedKoo Cat#: 574073 | Name: VH032 phenol - linker 2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH032 phenol - linker 2 is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. It incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand.

Chemical Structure

VH032 phenol - linker 2
VH032 phenol - linker 2
CAS#2376990-28-0

Theoretical Analysis

MedKoo Cat#: 574073

Name: VH032 phenol - linker 2

CAS#: 2376990-28-0

Chemical Formula: C30H47Cl2N5O5S

Exact Mass: 659.2675

Molecular Weight: 660.70

Elemental Analysis: C, 54.54; H, 7.17; Cl, 10.73; N, 10.60; O, 12.11; S, 4.85

Price and Availability

Size Price Availability Quantity
25mg USD 540.00
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Related CAS #
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Synonym
VH032 phenol - linker 2, VH 032 phenol - linker 2, VH-032 phenol - linker 2
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
InChi Key
ZDPHPLMGGQWIRY-SGROTYDGSA-N
InChi Code
InChI=1S/C30H45N5O5S.2ClH/c1-19-26(41-18-33-19)21-10-11-22(25(14-21)40-13-9-7-6-8-12-31)16-32-28(38)24-15-23(37)17-35(24)29(39)27(30(3,4)5)34-20(2)36;;/h10-11,14,18,23-24,27,37H,6-9,12-13,15-17,31H2,1-5H3,(H,32,38)(H,34,36);2*1H/t23-,24+,27-;;/m1../s1
SMILES Code
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2OCCCCCCN.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 660.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL