H10 is a peptide inhibitor that specifically targets anterior gradient 2 (AGR2), a protein implicated in cancer progression. It binds AGR2 with a dissociation constant (K_D) of 6.4 nM, effectively inhibiting cancer cell viability with an IC₅₀ between 9–12 μM. Additionally, H10 impedes cancer cell migration in breast and prostate cancer cell lines at concentrations of 10 μg/mL, highlighting its potential as a therapeutic agent in oncology.
MedKoo Cat#: 574072
Name: PARP14-IN-H10
CAS#: 2084811-68-5
Chemical Formula: C24H27N7O7S
Exact Mass: 557.1693
Molecular Weight: 557.58
Elemental Analysis: C, 51.70; H, 4.88; N, 17.58; O, 20.09; S, 5.75
The following data is based on the product molecular weight 557.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
