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MedKoo Cat#: 585249 | Name: TK 12627

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TK 12627 is an antioxidant that increases serum thyroxine (T4) levels and decreases free T3 concentrations.

Chemical Structure

TK 12627
CAS#36443-68-2

Theoretical Analysis

MedKoo Cat#: 585249

Name: TK 12627

CAS#: 36443-68-2

Chemical Formula: C40H62O8

Exact Mass: 670.4445

Molecular Weight: 670.93

Elemental Analysis: C, 71.61; H, 9.31; O, 19.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
TK 12627; TK12627; TK-12627
IUPAC/Chemical Name
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester
InChi Key
HZQMAGZJUOWDHN-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H62O8/c1-37(2,3)29-23-27(24-30(35(29)43)38(4,5)6)13-15-33(41)47-21-19-45-17-18-46-20-22-48-34(42)16-14-28-25-31(39(7,8)9)36(44)32(26-28)40(10,11)12/h23-26,43-44H,13-22H2,1-12H3
SMILES Code
O=C(OCCOCCOCCOC(CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O)CCC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 670.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang H, Morin O, Burger AG. Effect of the antioxidant TK 12627 (Irganox) on monodeiodination and on the levels of messenger ribonucleic acid of 5'-deiodinase type I and spot 14. Acta Endocrinol (Copenh). 1993 May;128(5):451-8. PubMed PMID: 8317193. 2: Muakkassah-Kelly SF, Krinke AL, Malinowski W, Stäubli W, Bentley P, Waechter F, Juge-Aubry C, Burger AG. The effect of short term feeding of the antioxidant triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate on serum thyrotropin and thyroid hormones in the male rat. Toxicol Appl Pharmacol. 1991 Jan;107(1):129-40. PubMed PMID: 1987652. 3: Waechter F, Beilstein P, Burger AG, O'Connell M, Fabreguettes C, Forster R, Weideli H. Subchronic toxicity study with ethylene-bis-(oxyethylene)-bis-(3-tert-butyl-4-hydroxy-5-methylhydro cin namate) in the cynomolgus monkey: lack of stimulation of the pituitary-thyroid-liver axis. Toxicol Sci. 1999 Sep;51(1):36-43. PubMed PMID: 10496675.

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