Synonym
TJN-331; TJN331; TJN 331
IUPAC/Chemical Name
(E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-3-pyridin-3-ylprop-2-enamide
InChi Key
FEIVGIWPNTVAOB-VQHVLOKHSA-N
InChi Code
InChI=1S/C19H22N2O3/c1-21(19(22)9-7-16-5-4-11-20-14-16)12-10-15-6-8-17(23-2)18(13-15)24-3/h4-9,11,13-14H,10,12H2,1-3H3/b9-7+
SMILES Code
O=C(N(CCC1=CC=C(OC)C(OC)=C1)C)/C=C/C2=CC=CN=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
326.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saegusa Y, Sadakane C, Koseki J, Hasegawa Y, Shindo S, Takeda S, Takeda H, Hattori T. (E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice. Clin Exp Nephrol. 2010 Dec;14(6):528-35. doi: 10.1007/s10157-010-0338-4. Epub 2010 Sep 4. PubMed PMID: 20814808.
2: Saegusa Y, Sadakane C, Koseki J, Hasegawa Y, Shindo S, Maruyama H, Takeda S, Takeda H, Hattori T. TJN-331 improves anti-glomerular basement membrane nephritis by inhibiting the production of intraglomerular transforming growth factor-beta1. Biol Pharm Bull. 2010;33(8):1349-54. PubMed PMID: 20686230.
3: Saegusa Y, Sadakane C, Koseki J, Hasegawa Y, Shindo S, Maruyama H, Kase Y, Takeda S, Takeda H, Hattori T. Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production. Biol Pharm Bull. 2010;33(10):1710-5. PubMed PMID: 20930380.
